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Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI
Sleep is necessary for the optimal consolidation of newly acquired procedural memories. However, the mechanisms by which motor memory traces develop during sleep remain controversial in humans, as this process has been mainly investigated indirectly by comparing pre- and post-sleep conditions. Here,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593513/ https://www.ncbi.nlm.nih.gov/pubmed/28892464 http://dx.doi.org/10.7554/eLife.24987 |
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author | Vahdat, Shahabeddin Fogel, Stuart Benali, Habib Doyon, Julien |
author_facet | Vahdat, Shahabeddin Fogel, Stuart Benali, Habib Doyon, Julien |
author_sort | Vahdat, Shahabeddin |
collection | PubMed |
description | Sleep is necessary for the optimal consolidation of newly acquired procedural memories. However, the mechanisms by which motor memory traces develop during sleep remain controversial in humans, as this process has been mainly investigated indirectly by comparing pre- and post-sleep conditions. Here, we used functional magnetic resonance imaging and electroencephalography during sleep following motor sequence learning to investigate how newly-formed memory traces evolve dynamically over time. We provide direct evidence for transient reactivation followed by downscaling of functional connectivity in a cortically-dominant pattern formed during learning, as well as gradual reorganization of this representation toward a subcortically-dominant consolidated trace during non-rapid eye movement (NREM) sleep. Importantly, the putamen functional connectivity within the consolidated network during NREM sleep was related to overnight behavioral gains. Our results demonstrate that NREM sleep is necessary for two complementary processes: the restoration and reorganization of newly-learned information during sleep, which underlie human motor memory consolidation. DOI: http://dx.doi.org/10.7554/eLife.24987.001 |
format | Online Article Text |
id | pubmed-5593513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55935132017-09-18 Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI Vahdat, Shahabeddin Fogel, Stuart Benali, Habib Doyon, Julien eLife Neuroscience Sleep is necessary for the optimal consolidation of newly acquired procedural memories. However, the mechanisms by which motor memory traces develop during sleep remain controversial in humans, as this process has been mainly investigated indirectly by comparing pre- and post-sleep conditions. Here, we used functional magnetic resonance imaging and electroencephalography during sleep following motor sequence learning to investigate how newly-formed memory traces evolve dynamically over time. We provide direct evidence for transient reactivation followed by downscaling of functional connectivity in a cortically-dominant pattern formed during learning, as well as gradual reorganization of this representation toward a subcortically-dominant consolidated trace during non-rapid eye movement (NREM) sleep. Importantly, the putamen functional connectivity within the consolidated network during NREM sleep was related to overnight behavioral gains. Our results demonstrate that NREM sleep is necessary for two complementary processes: the restoration and reorganization of newly-learned information during sleep, which underlie human motor memory consolidation. DOI: http://dx.doi.org/10.7554/eLife.24987.001 eLife Sciences Publications, Ltd 2017-09-11 /pmc/articles/PMC5593513/ /pubmed/28892464 http://dx.doi.org/10.7554/eLife.24987 Text en © 2017, Vahdat et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Vahdat, Shahabeddin Fogel, Stuart Benali, Habib Doyon, Julien Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI |
title | Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI |
title_full | Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI |
title_fullStr | Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI |
title_full_unstemmed | Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI |
title_short | Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI |
title_sort | network-wide reorganization of procedural memory during nrem sleep revealed by fmri |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593513/ https://www.ncbi.nlm.nih.gov/pubmed/28892464 http://dx.doi.org/10.7554/eLife.24987 |
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