Cargando…

Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling

Accumulation of β-catenin in the nucleus is a hallmark of activation of the Wnt/β-catenin signaling pathway, which drives development of a large proportion of human cancers. However, the mechanism of β-catenin nuclear translocation has not been well investigated. Here we report biological significan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Xiaolan, Hamamoto, Ryuji, Vougiouklakis, Theodore, Wang, Rui, Yoshioka, Yuichiro, Suzuki, Takehiro, Dohmae, Naoshi, Matsuo, Yo, Park, Jae-Hyun, Nakamura, Yusuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593527/ https://www.ncbi.nlm.nih.gov/pubmed/28915556 http://dx.doi.org/10.18632/oncotarget.19646

Ejemplares similares

Effects of SMYD2‐mediated EML4‐ALK methylation on the signaling pathway and growth in non‐small‐cell lung cancer cells
por: Wang, Rui, et al.
Publicado: (2017)

Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization
por: Yoshioka, Yuichiro, et al.
Publicado: (2017)

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1
por: Yoshioka, Yuichiro, et al.
Publicado: (2016)

SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells
por: Vougiouklakis, Theodore, et al.
Publicado: (2015)

PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP
por: Deng, Xiaolan, et al.
Publicado: (2015)

SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells
por: Piao, Lianhua, et al.
Publicado: (2015)

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN()()
por: Nakakido, Makoto, et al.
Publicado: (2015)

WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer
por: Saloura, Vassiliki, et al.
Publicado: (2017)

PRMT6 increases cytoplasmic localization of p21(CDKN1A) in cancer cells through arginine methylation and makes more resistant to cytotoxic agents
por: Nakakido, Makoto, et al.
Publicado: (2015)

Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins
por: Piao, Lianhua, et al.
Publicado: (2016)

Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis
por: Bagislar, Sevgi, et al.
Publicado: (2016)

WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck
por: Saloura, Vassiliki, et al.
Publicado: (2020)

UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3σ axis inhibits keratinocyte survival and proliferation
por: Kim, Mihwa, et al.
Publicado: (2017)

Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX
por: Vougiouklakis, Theodore, et al.
Publicado: (2018)

Aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms control lymphoid cancer cell proliferation through differentially regulating tumor suppressor p53 activity
por: Gardella, Kacie A., et al.
Publicado: (2016)

WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck
por: Saloura, Vassiliki, et al.
Publicado: (2016)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

β-catenin activation drives thymoma initiation and progression in mice
por: Liang, Chih-Chia, et al.
Publicado: (2015)

Nuclear translocation of beta-catenin in colorectal cancer
por: Kobayashi, M, et al.
Publicado: (2000)

Hypophosphatemia Due to Increased Effector Cell Metabolic Activity Is Associated with Neurotoxicity Symptoms in CD19-Targeted CAR T-cell Therapy
por: Tang, Jack Pengfei, et al.
Publicado: (2022)

Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis
por: Soutto, Mohammed, et al.
Publicado: (2015)

Neural circuit for psychological stress-induced hyperthermia
por: Nakamura, Kazuhiro
Publicado: (2015)

Activation of Intracellular Calcium by Multiple Wnt Ligands and Translocation of β-Catenin into the Nucleus: A CONVERGENT MODEL OF Wnt/Ca(2+) AND Wnt/β-CATENIN PATHWAYS
por: Thrasivoulou, Christopher, et al.
Publicado: (2013)

A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells
por: Tiwari, Rajiv L., et al.
Publicado: (2021)

Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling
por: Zhu, Bing, et al.
Publicado: (2017)

Differential Nuclear Translocation and Transactivation Potential of β-Catenin and Plakoglobin
por: Simcha, Inbal, et al.
Publicado: (1998)

A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model
por: Goldstein, Seth D., et al.
Publicado: (2016)

The nuclear import of ribosomal proteins is regulated by mTOR
por: Kazyken, Dubek, et al.
Publicado: (2014)

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling
por: Lamb, Rebecca, et al.
Publicado: (2015)

Clinical Significance of the Duality of Wnt/β-Catenin Signaling in Human Hepatocellular Carcinoma
por: Aoki, Tomoko, et al.
Publicado: (2022)

The histone methyltransferase SMYD2 is a novel therapeutic target for the induction of apoptosis in ovarian clear cell carcinoma cells
por: Kojima, Machiko, et al.
Publicado: (2020)

Protein methyltransferases and demethylases dictate CD8+ T-cell exclusion in squamous cell carcinoma of the head and neck
por: Vougiouklakis, Theodore, et al.
Publicado: (2017)

p53-independent p21 induction by MELK inhibition
por: Matsuda, Tatsuo, et al.
Publicado: (2017)

Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
por: Kim, Kwangho, et al.
Publicado: (2023)

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype
por: Xiang, Lisha, et al.
Publicado: (2014)

AMP-activated protein kinase-dependent nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in senescent human diploid fibroblasts
por: Sohn, Jee Young, et al.
Publicado: (2022)

Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy
por: Hamamoto, Ryuji, et al.
Publicado: (2016)

New Advances in Canonical Wnt/β-Catenin Signaling in Cancer
por: Wen, Xiaolan, et al.
Publicado: (2020)

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
por: Itoh, Keiji, et al.
Publicado: (2005)

Upregulation of SMYD3 and SMYD3 VNTR 3/3 polymorphism increase the risk of hepatocellular carcinoma
por: Binh, Mai Thanh, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e0a66moopladbg2vsknutn3plr