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Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease mainly characterized by cartilage degradation. Interleukin-1β (IL-1β) contributes to OA pathogenesis by enhancing oxidative stress and inflammation. Melatonin reportedly elicits potent protection against OA. However, the role of melatonin and under...

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Detalles Bibliográficos
Autores principales:	Guo, Jia Yi, Li, Feng, Wen, Yong Bing, Cui, Hong Xun, Guo, Ma Long, Zhang, Lin, Zhang, Yun Fei, Guo, Yan Jin, Guo, Yan Xing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper: Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593538/ https://www.ncbi.nlm.nih.gov/pubmed/28915567 http://dx.doi.org/10.18632/oncotarget.18356

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