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IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population

Renal cell carcinoma (RCC) is considered a cytokine-responsive tumor. However, with the lack of diagnostic screening biomarkers, early diagnosis of RCC is challenging. Our study was investigated the association of IL1 gene polymorphisms and RCC risk. We conducted a case-control study of 291 RCC case...

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Autores principales: Wang, Fei, Zhang, Yingai, Wang, Shunlan, Zhang, Yadong, Wu, Dinglan, Zhang, Chong, Gao, Yuanhui, Liu, Xi, Wang, Weifu, Zhang, Shufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593541/
https://www.ncbi.nlm.nih.gov/pubmed/28915570
http://dx.doi.org/10.18632/oncotarget.18715
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author Wang, Fei
Zhang, Yingai
Wang, Shunlan
Zhang, Yadong
Wu, Dinglan
Zhang, Chong
Gao, Yuanhui
Liu, Xi
Wang, Weifu
Zhang, Shufang
author_facet Wang, Fei
Zhang, Yingai
Wang, Shunlan
Zhang, Yadong
Wu, Dinglan
Zhang, Chong
Gao, Yuanhui
Liu, Xi
Wang, Weifu
Zhang, Shufang
author_sort Wang, Fei
collection PubMed
description Renal cell carcinoma (RCC) is considered a cytokine-responsive tumor. However, with the lack of diagnostic screening biomarkers, early diagnosis of RCC is challenging. Our study was investigated the association of IL1 gene polymorphisms and RCC risk. We conducted a case-control study of 291 RCC cases and 463 controls to evaluation the IL1RN of single nucleotide polymorphisms (SNPs) on RCC risk. We selection of 16 SNPs in IL1RN, IL1A, IL1B genes were analyzed. Using the chi-squared (χ(2)) test and genetic model analysis, we found an association with RCC risk for five SNPs [rs3783550 (IL1A), rs3783546 (IL1A), rs1609682 (IL1A), rs3783521 (IL1A), and rs1143623 (IL1B)] and increased the risk of RCC. Stratified analyses show that smoking, not drinking and age>55 populations relative to nonsmoking, drinking and age<55 more susceptible. Our study suggested that IL1B and IL1A may involve in the development of RCC in Chinese Han population.
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spelling pubmed-55935412017-09-14 IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population Wang, Fei Zhang, Yingai Wang, Shunlan Zhang, Yadong Wu, Dinglan Zhang, Chong Gao, Yuanhui Liu, Xi Wang, Weifu Zhang, Shufang Oncotarget Research Paper Renal cell carcinoma (RCC) is considered a cytokine-responsive tumor. However, with the lack of diagnostic screening biomarkers, early diagnosis of RCC is challenging. Our study was investigated the association of IL1 gene polymorphisms and RCC risk. We conducted a case-control study of 291 RCC cases and 463 controls to evaluation the IL1RN of single nucleotide polymorphisms (SNPs) on RCC risk. We selection of 16 SNPs in IL1RN, IL1A, IL1B genes were analyzed. Using the chi-squared (χ(2)) test and genetic model analysis, we found an association with RCC risk for five SNPs [rs3783550 (IL1A), rs3783546 (IL1A), rs1609682 (IL1A), rs3783521 (IL1A), and rs1143623 (IL1B)] and increased the risk of RCC. Stratified analyses show that smoking, not drinking and age>55 populations relative to nonsmoking, drinking and age<55 more susceptible. Our study suggested that IL1B and IL1A may involve in the development of RCC in Chinese Han population. Impact Journals LLC 2017-06-28 /pmc/articles/PMC5593541/ /pubmed/28915570 http://dx.doi.org/10.18632/oncotarget.18715 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Wang, Fei
Zhang, Yingai
Wang, Shunlan
Zhang, Yadong
Wu, Dinglan
Zhang, Chong
Gao, Yuanhui
Liu, Xi
Wang, Weifu
Zhang, Shufang
IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population
title IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population
title_full IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population
title_fullStr IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population
title_full_unstemmed IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population
title_short IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population
title_sort il1 genes polymorphism and the risk of renal cell carcinoma in chinese han population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593541/
https://www.ncbi.nlm.nih.gov/pubmed/28915570
http://dx.doi.org/10.18632/oncotarget.18715
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