FoxR2 promotes glioma proliferation by suppression of the p27 pathway

FoxR2 plays an important role in the development of many human tumors. However, the effects of FoxR2 on tumorigenicity of human glioma remain unclear. In this study, we investigated the roles of FoxR2 in cell proliferation and invasion of glioma. We found that overexpression of FoxR2 promoted the pr...

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Autores principales: Liu, Xuejiao, Liu, Ning, Yue, Chenglong, Wang, Dacheng, Qi, Zhenglei, Tu, Yiming, Zhuang, Guokun, Zhou, Di, Gao, Shangfeng, Niu, Mingshan, Yu, Rutong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593559/
https://www.ncbi.nlm.nih.gov/pubmed/28915588
http://dx.doi.org/10.18632/oncotarget.17447
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author Liu, Xuejiao
Liu, Ning
Yue, Chenglong
Wang, Dacheng
Qi, Zhenglei
Tu, Yiming
Zhuang, Guokun
Zhou, Di
Gao, Shangfeng
Niu, Mingshan
Yu, Rutong
author_facet Liu, Xuejiao
Liu, Ning
Yue, Chenglong
Wang, Dacheng
Qi, Zhenglei
Tu, Yiming
Zhuang, Guokun
Zhou, Di
Gao, Shangfeng
Niu, Mingshan
Yu, Rutong
author_sort Liu, Xuejiao
collection PubMed
description FoxR2 plays an important role in the development of many human tumors. However, the effects of FoxR2 on tumorigenicity of human glioma remain unclear. In this study, we investigated the roles of FoxR2 in cell proliferation and invasion of glioma. We found that overexpression of FoxR2 promoted the proliferation, migration and invasion of glioma cells. Knockout of FoxR2 induced G1 arrest by decreasing the expression levels of cyclin D1, cyclin E and p-Rb. Mechanistically, upregulation of FoxR2 increased the level and activity of MMP-2 and decreased the expression of p27. Furthermore, overexpression of FoxR2 decreased the nuclear accumulation of p27. Taken together, these results indicate that upregulation of FoxR2 may confer enhanced tumorigenicity in glioma cells.
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spelling pubmed-55935592017-09-14 FoxR2 promotes glioma proliferation by suppression of the p27 pathway Liu, Xuejiao Liu, Ning Yue, Chenglong Wang, Dacheng Qi, Zhenglei Tu, Yiming Zhuang, Guokun Zhou, Di Gao, Shangfeng Niu, Mingshan Yu, Rutong Oncotarget Research Paper FoxR2 plays an important role in the development of many human tumors. However, the effects of FoxR2 on tumorigenicity of human glioma remain unclear. In this study, we investigated the roles of FoxR2 in cell proliferation and invasion of glioma. We found that overexpression of FoxR2 promoted the proliferation, migration and invasion of glioma cells. Knockout of FoxR2 induced G1 arrest by decreasing the expression levels of cyclin D1, cyclin E and p-Rb. Mechanistically, upregulation of FoxR2 increased the level and activity of MMP-2 and decreased the expression of p27. Furthermore, overexpression of FoxR2 decreased the nuclear accumulation of p27. Taken together, these results indicate that upregulation of FoxR2 may confer enhanced tumorigenicity in glioma cells. Impact Journals LLC 2017-04-27 /pmc/articles/PMC5593559/ /pubmed/28915588 http://dx.doi.org/10.18632/oncotarget.17447 Text en Copyright: © 2017 Liu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Liu, Xuejiao
Liu, Ning
Yue, Chenglong
Wang, Dacheng
Qi, Zhenglei
Tu, Yiming
Zhuang, Guokun
Zhou, Di
Gao, Shangfeng
Niu, Mingshan
Yu, Rutong
FoxR2 promotes glioma proliferation by suppression of the p27 pathway
title FoxR2 promotes glioma proliferation by suppression of the p27 pathway
title_full FoxR2 promotes glioma proliferation by suppression of the p27 pathway
title_fullStr FoxR2 promotes glioma proliferation by suppression of the p27 pathway
title_full_unstemmed FoxR2 promotes glioma proliferation by suppression of the p27 pathway
title_short FoxR2 promotes glioma proliferation by suppression of the p27 pathway
title_sort foxr2 promotes glioma proliferation by suppression of the p27 pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593559/
https://www.ncbi.nlm.nih.gov/pubmed/28915588
http://dx.doi.org/10.18632/oncotarget.17447
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