Cargando…

Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways

Baicalein, a flavone ingredient of Scutellaria baicalensis Georgi, is a promising anti-cancer agent. However, its potential anti-pancreatic cancer effects and the underlying mechanisms are still unclear. In this study, we showed that Baicalein not only induced apoptosis, but also suppressed prolifer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Rong-Tao, He, Mei, Yu, Ze, Liang, Yang, Nie, Yuzhe, Tai, Sheng, Teng, Chun-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593566/ https://www.ncbi.nlm.nih.gov/pubmed/28915595 http://dx.doi.org/10.18632/oncotarget.16912

Ejemplares similares

MicroRNA-145 suppresses cell proliferation, invasion and migration in pancreatic cancer cells by targeting NEDD9
por: HAN, TONG, et al.
Publicado: (2015)

siRNA Suppression of NEDD9 Inhibits Proliferation and Enhances Apoptosis in Renal Cell Carcinoma
por: Wang, Jue, et al.
Publicado: (2015)

Characterization of MRFAP1 Turnover and Interactions Downstream of the NEDD8 Pathway
por: Larance, Mark, et al.
Publicado: (2012)

Clinical Significance of Serum NEDD9 Levels in Patients with Pancreatic Cancer
por: Afsar, Cigdem Usul, et al.
Publicado: (2018)

miR-18a counteracts AKT and ERK activation to inhibit the proliferation of pancreatic progenitor cells
por: Li, Xuyan, et al.
Publicado: (2017)

Anticancer Effects of Baicalein in Pancreatic Neuroendocrine Tumors In Vitro and In Vivo
por: Tian, Ye, et al.
Publicado: (2017)

Baicalein ameliorates osteoporosis via AKT/FOXO1 signaling
por: Cai, Pan, et al.
Publicado: (2021)

ERas regulates cell proliferation and epithelial–mesenchymal transition by affecting Erk/Akt signaling pathway in pancreatic cancer
por: Liu, Yang, et al.
Publicado: (2020)

miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9
por: Zheng, Hong, et al.
Publicado: (2022)

Combined Effects of Baicalein and Docetaxel on Apoptosis in 8505c Anaplastic Thyroid Cancer Cells via Downregulation of the ERK and Akt/mTOR Pathways
por: Park, Chan Ho, et al.
Publicado: (2018)

Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade
por: Yang, Qian, et al.
Publicado: (2020)

Baicalein suppresses the proliferation and invasiveness of colorectal cancer cells by inhibiting Snail-induced epithelial-mesenchymal transition
por: Zeng, Qiongyao, et al.
Publicado: (2020)

Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation
por: Shao, Zuohui, et al.
Publicado: (2018)

N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21
por: Zhang, Sen, et al.
Publicado: (2019)

Dracohodin Perochlorate Stimulates Fibroblast Proliferation via EGFR Activation and Downstream ERK/CREB and PI3K/Akt/mTOR Pathways In Vitro
por: Liu, Lin, et al.
Publicado: (2019)

Anti-Proliferative and Apoptosis-Promoting Effect of microRNA-125b on Pancreatic Cancer by Targeting NEDD9 via PI3K/AKT Signaling
por: Xue, Yuzheng, et al.
Publicado: (2020)

Role of NEDD9 in invasion and metastasis of lung adenocarcinoma
por: CHANG, JING-XIA, et al.
Publicado: (2012)

EXPRESSION OF NEDD9 IN TRANSBRONCHIAL BIOPSIES OF LUNG ADENOCARCINOMA
por: Ostojić, Jelena, et al.
Publicado: (2018)

NEDD9 sustains hexokinase expression to promote glycolysis
por: Deneka, Alexander Y., et al.
Publicado: (2022)

Corrigendum to “Dracohodin Perochlorate Stimulates Fibroblast Proliferation via EGFR Activation and Downstream ERK/CREB and PI3K/Akt/mTOR Pathways In Vitro”
por: Liu, Lin, et al.
Publicado: (2020)

The interaction between cucurbit[8]uril and baicalein and the effect on baicalein properties
por: Zhang, Xiaodong, et al.
Publicado: (2020)

Liver proliferation: The GUCD1/NEDD4–1 connection
por: Calvisi, Diego F
Publicado: (2014)

Baicalein Inhibits the Invasion and Metastatic Capabilities of Hepatocellular Carcinoma Cells via Down-Regulation of the ERK Pathway
por: Chen, Kunlun, et al.
Publicado: (2013)

NEDD9 provides mechanistic insight into the coagulopathy of COVID‐19
por: Rizzo, Alicia N., et al.
Publicado: (2022)

Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9
por: Hsieh, Min-Hong, et al.
Publicado: (2019)

Targeting TF-AKT/ERK-EGFR Pathway Suppresses the Growth of Hepatocellular Carcinoma
por: Huang, Shan-Zhou, et al.
Publicado: (2019)

Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation
por: Li, Bin, et al.
Publicado: (2021)

UVB induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes
por: Ming, Mei, et al.
Publicado: (2009)

Inhibitory effect of baicalein combined with gemcitabine in human pancreatic cancer cell lines
por: Li, Zhenlei, et al.
Publicado: (2018)

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation
por: Vega, Mario, et al.
Publicado: (2022)

PDCD10 promotes the aggressive behaviors of pituitary adenomas by up-regulating CXCR2 and activating downstream AKT/ERK signaling
por: Liu, Jingdian, et al.
Publicado: (2022)

Melatonin suppresses TLR9-triggered proinflammatory cytokine production in macrophages by inhibiting ERK1/2 and AKT activation
por: Xu, Xiongfei, et al.
Publicado: (2018)

Nitidine chloride suppresses NEDD4 expression in lung cancer cells
por: Zhang, Jing, et al.
Publicado: (2020)

A complex RARE is required for the majority of Nedd9 embryonic expression
por: Knutson, Danielle C., et al.
Publicado: (2014)

Elevated expression of NEDD9 is associated with metastatic activity in gastric cancer
por: Zhang, Si-sen, et al.
Publicado: (2015)

NEDD9 overexpression: Prognostic and guidance value in acute myeloid leukaemia
por: Hua, Shenghao, et al.
Publicado: (2021)

A SLC31A1-MEK-DNMT1-miR-124 feedback loop contributes to pancreatic cancer progression
por: Jin, Jing, et al.
Publicado: (2022)

Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK
por: Yuan-Ce, Li, et al.
Publicado: (2023)

Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway
por: Lai, Huanling, et al.
Publicado: (2018)

Baicalein Protects Rats with Diabetic Cardiomyopathy Against Oxidative Stress and Inflammation Injury via Phosphatidylinositol 3-Kinase (PI3K)/AKT Pathway
por: Ma, Lin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_r8cio5rerqglcmiq3jv8ljaghf