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Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation

INTRODUCTION AND AIMS: Osteolytic bone metastases are observed in advanced cases of breast cancer. In vitro data suggest that the activity of the calcium-sensing receptor (CaSR) expressed by metastatic cells could potentiate their osteolytic potential. This study aimed to demonstrate in vivo the inv...

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Detalles Bibliográficos
Autores principales:	Boudot, Cédric, Hénaut, Lucie, Thiem, Ursula, Geraci, Sandra, Galante, Mariangela, Saldanha, Paulo, Saidak, Zuzana, Six, Isabelle, Clézardin, Philippe, Kamel, Said, Mentaverri, Romuald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593575/ https://www.ncbi.nlm.nih.gov/pubmed/28915604 http://dx.doi.org/10.18632/oncotarget.16999

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