Cargando…

BTK suppresses myeloma cellular senescence through activating AKT/P27/Rb signaling

We previously explored the role of BTK in maintaining multiple myeloma stem cells (MMSCs) self-renewal and drug-resistance. Here we investigated the elevation of BTK suppressing MM cellular senescence, a state of irreversible cellular growth arrest. We firstly discovered that an increased expression...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Chunyan, Peng, Hailin, Lu, Yue, Yang, Hongbao, Tian, Zhidan, Yin, Gang, Zhang, Wen, Lu, Sicheng, Zhang, Yi, Yang, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593608/ https://www.ncbi.nlm.nih.gov/pubmed/28915637 http://dx.doi.org/10.18632/oncotarget.18096

Ejemplares similares

MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment
por: Gu, Chunyan, et al.
Publicado: (2015)

Ginsenoside Rb2 suppresses cellular senescence of human dermal fibroblasts by inducing autophagy
por: Yang, Kyeong Eun, et al.
Publicado: (2023)

Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68
por: Yaung, Stephanie J., et al.
Publicado: (2015)

MK2 is a therapeutic target for high-risk multiple myeloma
por: Gu, Chunyan, et al.
Publicado: (2018)

Role of Bruton's tyrosine kinase (BTK) in growth and metastasis of INA6 myeloma cells
por: Bam, R, et al.
Publicado: (2014)

Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma
por: Dou, Renjie, et al.
Publicado: (2021)

Lycorine hydrochloride suppresses stress‐induced premature cellular senescence by stabilizing the genome of human cells
por: Zhang, Weina, et al.
Publicado: (2021)

Complete senescence: RB and PML share the task
por: Vernier, Mathieu, et al.
Publicado: (2014)

Splicing factor arginine/serine‐rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome‐based cellular communication
por: Zhang, Yuanjiao, et al.
Publicado: (2022)

Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway
por: Zhou, Wenjing, et al.
Publicado: (2018)

Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK
por: Kueffer, Lauren E., et al.
Publicado: (2021)

Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors
por: Qi, Jialei, et al.
Publicado: (2023)

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway
por: Warnier, Marine, et al.
Publicado: (2018)

BTK: a two-faced effector in cancer and tumour suppression
por: Rada, Miran, et al.
Publicado: (2018)

Chromosomal instability and acquired drug resistance in multiple myeloma
por: Wang, Wang, et al.
Publicado: (2017)

Sesamin Metabolites Suppress the Induction of Cellular Senescence
por: Araki, Chie, et al.
Publicado: (2023)

Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways
por: Fu, Cong, et al.
Publicado: (2015)

Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymphoma
por: Jiang, Vivian Changying, et al.
Publicado: (2023)

Effect of etoposide-induced alteration of the Mdm2-Rb signaling pathway on cellular senescence in A549 lung adenocarcinoma cells
por: Dai, Wenjing, et al.
Publicado: (2017)

Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model
por: Wu, Hong, et al.
Publicado: (2017)

BTK inhibitors impair humoral and cellular responses to recombinant zoster vaccine in CLL
por: Pleyer, Christopher, et al.
Publicado: (2022)

Circulating versus cellular tumor DNA for the detection of BTK resistant CLL clones
por: Trummer, Arne, et al.
Publicado: (2022)

Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response
por: Du, Hekang, et al.
Publicado: (2023)

lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence
por: Shuai, Tian, et al.
Publicado: (2021)

Comparative Studies of Pectinase Production by Bacillus subtilis strain Btk 27 in Submerged and Solid-State Fermentations
por: Oumer, Oliyad Jeilu, et al.
Publicado: (2018)

P1239: BRUTON TYROSINE KINASE (BTK) PROTEIN DEGRADER BGB-16673 IS LESS APT TO CAUSE, AND ABLE TO OVERCOME VARIABLE BTK RESISTANCE MUTATIONS COMPARED TO OTHER BTK INHIBITORS (BTKI)
por: Feng, Xiaoyu, et al.
Publicado: (2023)

Irreversibility of cellular senescence: dual roles of p16(INK4a)/Rb-pathway in cell cycle control
por: Takahashi, Akiko, et al.
Publicado: (2007)

Inhibitory role of ginsenoside Rb2 in endothelial senescence and inflammation mediated by microRNA-216a
por: Chen, Yutong, et al.
Publicado: (2021)

ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK
por: Song, Peiran, et al.
Publicado: (2022)

Discovery of a potent BTK and IKZF1/3 triple degrader through reversible covalent BTK PROTAC development
por: Yu, Xin, et al.
Publicado: (2022)

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK
por: Joseph, Raji E, et al.
Publicado: (2020)

Bruton's tyrosine kinase (Btk) inhibitor tirabrutinib suppresses osteoclastic bone resorption
por: Ariza, Yuko, et al.
Publicado: (2019)

Human T-bet(+) B cell development is associated with BTK activity and suppressed by evobrutinib
por: Rijvers, Liza, et al.
Publicado: (2022)

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL
por: Zhang, Ying, et al.
Publicado: (2019)

Using high-sensitivity sequencing for the detection of mutations in BTK and PLCγ2 genes in cellular and cell-free DNA and correlation with progression in patients treated with BTK inhibitors
por: Albitar, Adam, et al.
Publicado: (2017)

LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473
por: Zhang, Yuanjiao, et al.
Publicado: (2023)

Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma
por: Feng, Qilin, et al.
Publicado: (2020)

The ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway
por: Rajarajacholan, Uma Karthika, et al.
Publicado: (2013)

The Paradoxical Role of Cellular Senescence in Cancer
por: Yang, Jing, et al.
Publicado: (2021)

E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability
por: Fukuyo, Yayoi, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_77icjft5f2ef55uj1vopn8poj4