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Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network

Digoxin is widely used to treat various heart conditions. In order to clarify the association between digoxin and anemia adverse reaction, we inspected case reports submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These reports involved 75618 atrial...

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Autores principales: Lin, Yubi, He, Siqi, Feng, Ruiling, Xu, Zhe, Chen, Wanqun, Huang, Zifeng, Liu, Yang, Zhang, Qianhuan, Zhang, Bin, Wang, Kejian, Wu, Shulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593620/
https://www.ncbi.nlm.nih.gov/pubmed/28915649
http://dx.doi.org/10.18632/oncotarget.18504
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author Lin, Yubi
He, Siqi
Feng, Ruiling
Xu, Zhe
Chen, Wanqun
Huang, Zifeng
Liu, Yang
Zhang, Qianhuan
Zhang, Bin
Wang, Kejian
Wu, Shulin
author_facet Lin, Yubi
He, Siqi
Feng, Ruiling
Xu, Zhe
Chen, Wanqun
Huang, Zifeng
Liu, Yang
Zhang, Qianhuan
Zhang, Bin
Wang, Kejian
Wu, Shulin
author_sort Lin, Yubi
collection PubMed
description Digoxin is widely used to treat various heart conditions. In order to clarify the association between digoxin and anemia adverse reaction, we inspected case reports submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These reports involved 75618 atrial fibrillation patients and 15699 heart failure patients. Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14–1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33–1.59–, P =4.27×10(−5)). We further explored previously published evidences and found 821 human genes directly or indirectly interacting with digoxin. Functional analysis indicated that these genes were significantly enriched in the biological processes of iron transport, which are closely related to iron deficiency anemia. Taken together, our retrospective analysis demonstrated the significant association between digoxin treatment and anemia adverse reaction, which should be seriously considered in clinical practice. Functional enrichment analysis on digoxin-related genes warranted subsequent research on the underlying toxicological mechanisms.
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spelling pubmed-55936202017-09-14 Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network Lin, Yubi He, Siqi Feng, Ruiling Xu, Zhe Chen, Wanqun Huang, Zifeng Liu, Yang Zhang, Qianhuan Zhang, Bin Wang, Kejian Wu, Shulin Oncotarget Research Paper Digoxin is widely used to treat various heart conditions. In order to clarify the association between digoxin and anemia adverse reaction, we inspected case reports submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These reports involved 75618 atrial fibrillation patients and 15699 heart failure patients. Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14–1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33–1.59–, P =4.27×10(−5)). We further explored previously published evidences and found 821 human genes directly or indirectly interacting with digoxin. Functional analysis indicated that these genes were significantly enriched in the biological processes of iron transport, which are closely related to iron deficiency anemia. Taken together, our retrospective analysis demonstrated the significant association between digoxin treatment and anemia adverse reaction, which should be seriously considered in clinical practice. Functional enrichment analysis on digoxin-related genes warranted subsequent research on the underlying toxicological mechanisms. Impact Journals LLC 2017-06-16 /pmc/articles/PMC5593620/ /pubmed/28915649 http://dx.doi.org/10.18632/oncotarget.18504 Text en Copyright: © 2017 Lin et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Lin, Yubi
He, Siqi
Feng, Ruiling
Xu, Zhe
Chen, Wanqun
Huang, Zifeng
Liu, Yang
Zhang, Qianhuan
Zhang, Bin
Wang, Kejian
Wu, Shulin
Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network
title Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network
title_full Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network
title_fullStr Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network
title_full_unstemmed Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network
title_short Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network
title_sort digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593620/
https://www.ncbi.nlm.nih.gov/pubmed/28915649
http://dx.doi.org/10.18632/oncotarget.18504
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