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Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review
CD73 is a glycosylphosphatidylinositol (GPI) anchored cell surface protein that is encoded by NT5E gene, plays multiple roles in tumor processes. Previous studies have presented a potential value of CD73 served as a detectable biomarker for prognosis of several solid tumors, but the results were mor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593644/ https://www.ncbi.nlm.nih.gov/pubmed/28915673 http://dx.doi.org/10.18632/oncotarget.16905 |
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author | Wang, Rong Zhang, Yingying Lin, Xia Gao, Yalin Zhu, Ying |
author_facet | Wang, Rong Zhang, Yingying Lin, Xia Gao, Yalin Zhu, Ying |
author_sort | Wang, Rong |
collection | PubMed |
description | CD73 is a glycosylphosphatidylinositol (GPI) anchored cell surface protein that is encoded by NT5E gene, plays multiple roles in tumor processes. Previous studies have presented a potential value of CD73 served as a detectable biomarker for prognosis of several solid tumors, but the results were more controversially. A comprehensive meta-analysis was conducted to precisely evaluate the prognostic role of CD73 in solid tumors. The included studies were searched in PubMed, Web of Science and EBSCO from Jan 1990 to Jan 2016. Pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI) for overall survival (OS), disease free survival (DFS) were carried out using a fixed or random effects model. Totally, 13 studies about 12,533 patients were included. CD73-high expression was correlating with poor OS (pooled HR = 1.28, 95% CI = 1.19–1.37). In addition, CD73 expression had borderline association with worse DFS (pooled HR = 1.28, 95% CI = 1.01–1.62). Egger’s tests indicated that there was no evidence of significant publication bias. CD73 is an efficient prognostic biomarker in solid tumors, and over-expression of CD73 is associated with inverse OS or DFS. But this predictive value and target therapy for clinical practice yet needs advanced research. |
format | Online Article Text |
id | pubmed-5593644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55936442017-09-14 Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review Wang, Rong Zhang, Yingying Lin, Xia Gao, Yalin Zhu, Ying Oncotarget Meta-Analysis CD73 is a glycosylphosphatidylinositol (GPI) anchored cell surface protein that is encoded by NT5E gene, plays multiple roles in tumor processes. Previous studies have presented a potential value of CD73 served as a detectable biomarker for prognosis of several solid tumors, but the results were more controversially. A comprehensive meta-analysis was conducted to precisely evaluate the prognostic role of CD73 in solid tumors. The included studies were searched in PubMed, Web of Science and EBSCO from Jan 1990 to Jan 2016. Pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI) for overall survival (OS), disease free survival (DFS) were carried out using a fixed or random effects model. Totally, 13 studies about 12,533 patients were included. CD73-high expression was correlating with poor OS (pooled HR = 1.28, 95% CI = 1.19–1.37). In addition, CD73 expression had borderline association with worse DFS (pooled HR = 1.28, 95% CI = 1.01–1.62). Egger’s tests indicated that there was no evidence of significant publication bias. CD73 is an efficient prognostic biomarker in solid tumors, and over-expression of CD73 is associated with inverse OS or DFS. But this predictive value and target therapy for clinical practice yet needs advanced research. Impact Journals LLC 2017-04-06 /pmc/articles/PMC5593644/ /pubmed/28915673 http://dx.doi.org/10.18632/oncotarget.16905 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Meta-Analysis Wang, Rong Zhang, Yingying Lin, Xia Gao, Yalin Zhu, Ying Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review |
title | Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review |
title_full | Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review |
title_fullStr | Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review |
title_full_unstemmed | Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review |
title_short | Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review |
title_sort | prognositic value of cd73-adenosinergic pathway in solid tumor: a meta-analysis and systematic review |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593644/ https://www.ncbi.nlm.nih.gov/pubmed/28915673 http://dx.doi.org/10.18632/oncotarget.16905 |
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