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Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis

OBJECTIVE: The relation between P73 gene polymorphism and cervical cancer has not been determined. At present, we utilized a meta-analysis method to elucidate the association between P73 and cervical cancer. RESULTS: The present study included 635 patients with cervical cancer and 998 cancer-free co...

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Autores principales: Liang, Xianghua, Chen, Bingxiang, Zhong, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593652/
https://www.ncbi.nlm.nih.gov/pubmed/28915681
http://dx.doi.org/10.18632/oncotarget.18164
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author Liang, Xianghua
Chen, Bingxiang
Zhong, Jianxin
author_facet Liang, Xianghua
Chen, Bingxiang
Zhong, Jianxin
author_sort Liang, Xianghua
collection PubMed
description OBJECTIVE: The relation between P73 gene polymorphism and cervical cancer has not been determined. At present, we utilized a meta-analysis method to elucidate the association between P73 and cervical cancer. RESULTS: The present study included 635 patients with cervical cancer and 998 cancer-free control subjects. Using meta-analysis, we found a significant association of P73 genetic polymorphism with cervical cancer in a recessive model [OR = 0.91, 95% CI: 0.84−0.98; P = 0.02.]. However, this association was not find in a dominant model [OR = 0.76, 95% CI (0.45−1.27); P = 0.29], in a co-dominant model [OR = 1.01; 95% CI: 0.98–1.04, P = 0.56] or in an allelic model [OR = 0.97, 95% CI: 0.93−1.00; P = 0.09]. MATERIALS AND METHODS: To further evaluate the relation between the P73 gene polymorphism and cervical cancer, we selected 5 case-control studies related to P73 gene polymorphism and cervical cancer by searching CNKI, VIP, WanFang, PubMed and EMbase database. We utilized Q-test and I(2) test to test the heterogeneity between each study. The fixed effects model was utilized to calculate the odds ratio (OR) and its 95% confidence interval. CONCLUSIONS: Our results suggest that P73 gene polymorphism was associated with the risk of cervical cancer. However, our conclusion still requires large sample size of case-control studies or cohort studies to further confirm this result.
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spelling pubmed-55936522017-09-14 Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis Liang, Xianghua Chen, Bingxiang Zhong, Jianxin Oncotarget Meta-Analysis OBJECTIVE: The relation between P73 gene polymorphism and cervical cancer has not been determined. At present, we utilized a meta-analysis method to elucidate the association between P73 and cervical cancer. RESULTS: The present study included 635 patients with cervical cancer and 998 cancer-free control subjects. Using meta-analysis, we found a significant association of P73 genetic polymorphism with cervical cancer in a recessive model [OR = 0.91, 95% CI: 0.84−0.98; P = 0.02.]. However, this association was not find in a dominant model [OR = 0.76, 95% CI (0.45−1.27); P = 0.29], in a co-dominant model [OR = 1.01; 95% CI: 0.98–1.04, P = 0.56] or in an allelic model [OR = 0.97, 95% CI: 0.93−1.00; P = 0.09]. MATERIALS AND METHODS: To further evaluate the relation between the P73 gene polymorphism and cervical cancer, we selected 5 case-control studies related to P73 gene polymorphism and cervical cancer by searching CNKI, VIP, WanFang, PubMed and EMbase database. We utilized Q-test and I(2) test to test the heterogeneity between each study. The fixed effects model was utilized to calculate the odds ratio (OR) and its 95% confidence interval. CONCLUSIONS: Our results suggest that P73 gene polymorphism was associated with the risk of cervical cancer. However, our conclusion still requires large sample size of case-control studies or cohort studies to further confirm this result. Impact Journals LLC 2017-05-24 /pmc/articles/PMC5593652/ /pubmed/28915681 http://dx.doi.org/10.18632/oncotarget.18164 Text en Copyright: © 2017 Liang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Meta-Analysis
Liang, Xianghua
Chen, Bingxiang
Zhong, Jianxin
Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis
title Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis
title_full Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis
title_fullStr Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis
title_full_unstemmed Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis
title_short Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis
title_sort association of p73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593652/
https://www.ncbi.nlm.nih.gov/pubmed/28915681
http://dx.doi.org/10.18632/oncotarget.18164
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