Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis

OBJECTIVE: The relation between P73 gene polymorphism and cervical cancer has not been determined. At present, we utilized a meta-analysis method to elucidate the association between P73 and cervical cancer. RESULTS: The present study included 635 patients with cervical cancer and 998 cancer-free control subjects. Using meta-analysis, we found a significant association of P73 genetic polymorphism with cervical cancer in a recessive model [OR = 0.91, 95% CI: 0.84−0.98; P = 0.02.]. However, this association was not find in a dominant model [OR = 0.76, 95% CI (0.45−1.27); P = 0.29], in a co-dominant model [OR = 1.01; 95% CI: 0.98–1.04, P = 0.56] or in an allelic model [OR = 0.97, 95% CI: 0.93−1.00; P = 0.09]. MATERIALS AND METHODS: To further evaluate the relation between the P73 gene polymorphism and cervical cancer, we selected 5 case-control studies related to P73 gene polymorphism and cervical cancer by searching CNKI, VIP, WanFang, PubMed and EMbase database. We utilized Q-test and I(2) test to test the heterogeneity between each study. The fixed effects model was utilized to calculate the odds ratio (OR) and its 95% confidence interval. CONCLUSIONS: Our results suggest that P73 gene polymorphism was associated with the risk of cervical cancer. However, our conclusion still requires large sample size of case-control studies or cohort studies to further confirm this result.