Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies

Lung cancer is one of the most common causes of cancer-related death in the world. The large number of lung cancer cases is non-small cell lung cancer (NSCLC), which approximately accounting for 75% of lung cancer. Over the past years, our comprehensive knowledge about the molecular biology of NSCLC...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Qing-Ge, Zhang, Shi-Ming, Ding, Xiao-Xiao, He, Bing, Zhang, Hu-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593676/
https://www.ncbi.nlm.nih.gov/pubmed/28915704
http://dx.doi.org/10.18632/oncotarget.17016
Descripción
Sumario:Lung cancer is one of the most common causes of cancer-related death in the world. The large number of lung cancer cases is non-small cell lung cancer (NSCLC), which approximately accounting for 75% of lung cancer. Over the past years, our comprehensive knowledge about the molecular biology of NSCLC has been rapidly enriching, which has promoted the discovery of driver genes in NSCLC and directed FDA-approved targeted therapies. Of course, the targeted therapies based on driver genes provide a more exact option for advanced non-small cell lung cancer, improving the survival rate of patients. Now, we will review the landscape of driver genes in NSCLC including the characteristics, detection methods, the application of target therapy and challenges.

Ejemplares similares