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The role of autophagy in hepatocellular carcinoma: friend or foe

Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which degrades cell’s components in order to recycle substrates to exert optimally and adapt to tough circumstances. It is a critical cellular homeostatic mechanism with stress resistance, immunity, antiaging, and pro-tumo...

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Autores principales: Liu, Lian, Liao, Jia-Zhi, He, Xing-Xing, Li, Pei-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593678/
https://www.ncbi.nlm.nih.gov/pubmed/28915706
http://dx.doi.org/10.18632/oncotarget.17202
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author Liu, Lian
Liao, Jia-Zhi
He, Xing-Xing
Li, Pei-Yuan
author_facet Liu, Lian
Liao, Jia-Zhi
He, Xing-Xing
Li, Pei-Yuan
author_sort Liu, Lian
collection PubMed
description Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which degrades cell’s components in order to recycle substrates to exert optimally and adapt to tough circumstances. It is a critical cellular homeostatic mechanism with stress resistance, immunity, antiaging, and pro-tumor or anti-tumor effects. Among these, the role of autophagy in cancer is the most eye-catching that is not immutable but dynamic and highly complex. Basal autophagy acts as a tumor suppressor by maintaining genomic stability in normal cells. However, once a tumor is established, unbalanced autophagy will contribute to carcinoma cell survival under tumor microenvironment and in turn promote tumor growth and development. The dynamic role of autophagy can also apply on hepatocellular carcinoma (HCC). HCC is a highly malignant cancer with high morbidity and poor survival rate. Decline or overexpression of autophagic essential genes such as ATG7, ATG5 or Beclin 1 plays a key role in the occurrence and development of HCC but the exact mechanisms are still highly controversial. Signaling pathways or molecules involving in autophagy, for example PI3K/AKT/mTOR pathway, ERK/MAPK pathway, PERK pathway, p53, LncRNA PTENP1 (Long non-coding RNA PTENP1), microRNA-375 and so on, occupy an important position in the complex role of autophagy in HCC. Here, we discuss the dynamic role, the signaling pathways and the potential prognostic and therapy value of autophagy in HCC.
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spelling pubmed-55936782017-09-14 The role of autophagy in hepatocellular carcinoma: friend or foe Liu, Lian Liao, Jia-Zhi He, Xing-Xing Li, Pei-Yuan Oncotarget Review Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which degrades cell’s components in order to recycle substrates to exert optimally and adapt to tough circumstances. It is a critical cellular homeostatic mechanism with stress resistance, immunity, antiaging, and pro-tumor or anti-tumor effects. Among these, the role of autophagy in cancer is the most eye-catching that is not immutable but dynamic and highly complex. Basal autophagy acts as a tumor suppressor by maintaining genomic stability in normal cells. However, once a tumor is established, unbalanced autophagy will contribute to carcinoma cell survival under tumor microenvironment and in turn promote tumor growth and development. The dynamic role of autophagy can also apply on hepatocellular carcinoma (HCC). HCC is a highly malignant cancer with high morbidity and poor survival rate. Decline or overexpression of autophagic essential genes such as ATG7, ATG5 or Beclin 1 plays a key role in the occurrence and development of HCC but the exact mechanisms are still highly controversial. Signaling pathways or molecules involving in autophagy, for example PI3K/AKT/mTOR pathway, ERK/MAPK pathway, PERK pathway, p53, LncRNA PTENP1 (Long non-coding RNA PTENP1), microRNA-375 and so on, occupy an important position in the complex role of autophagy in HCC. Here, we discuss the dynamic role, the signaling pathways and the potential prognostic and therapy value of autophagy in HCC. Impact Journals LLC 2017-04-18 /pmc/articles/PMC5593678/ /pubmed/28915706 http://dx.doi.org/10.18632/oncotarget.17202 Text en Copyright: © 2017 Liu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Liu, Lian
Liao, Jia-Zhi
He, Xing-Xing
Li, Pei-Yuan
The role of autophagy in hepatocellular carcinoma: friend or foe
title The role of autophagy in hepatocellular carcinoma: friend or foe
title_full The role of autophagy in hepatocellular carcinoma: friend or foe
title_fullStr The role of autophagy in hepatocellular carcinoma: friend or foe
title_full_unstemmed The role of autophagy in hepatocellular carcinoma: friend or foe
title_short The role of autophagy in hepatocellular carcinoma: friend or foe
title_sort role of autophagy in hepatocellular carcinoma: friend or foe
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593678/
https://www.ncbi.nlm.nih.gov/pubmed/28915706
http://dx.doi.org/10.18632/oncotarget.17202
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