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Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions
Ataxia telangiectasia mutated (ATM) gene mutations may confer increased sensitivity to ionizing radiation and increased risk of late toxicity for cancer patients. We present the case of a 55-year-old female treated with adjuvant breast and regional nodal radiation following lumpectomy and axillary l...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593749/ https://www.ncbi.nlm.nih.gov/pubmed/28929041 http://dx.doi.org/10.7759/cureus.1458 |
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author | Dosani, Maryam Schrader, Kasmintan A Nichol, Alan Sun, Sophie Shenkier, Tamara Lohn, Zoe Aubertin, Gudrun Tyldesley, Scott |
author_facet | Dosani, Maryam Schrader, Kasmintan A Nichol, Alan Sun, Sophie Shenkier, Tamara Lohn, Zoe Aubertin, Gudrun Tyldesley, Scott |
author_sort | Dosani, Maryam |
collection | PubMed |
description | Ataxia telangiectasia mutated (ATM) gene mutations may confer increased sensitivity to ionizing radiation and increased risk of late toxicity for cancer patients. We present the case of a 55-year-old female treated with adjuvant breast and regional nodal radiation following lumpectomy and axillary lymph node dissection for stage II invasive ductal carcinoma of the breast. She developed severe telangiectasia, fibrosis, induration, chest wall pain (with evidence of rib fractures on imaging), and painful limitation in her range of motion at the shoulder. She was subsequently found to have a likely pathogenic germline ATM gene mutation. At relapse, she elected to pursue systemic therapy alone for intracranial metastases. |
format | Online Article Text |
id | pubmed-5593749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-55937492017-09-19 Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions Dosani, Maryam Schrader, Kasmintan A Nichol, Alan Sun, Sophie Shenkier, Tamara Lohn, Zoe Aubertin, Gudrun Tyldesley, Scott Cureus Oncology Ataxia telangiectasia mutated (ATM) gene mutations may confer increased sensitivity to ionizing radiation and increased risk of late toxicity for cancer patients. We present the case of a 55-year-old female treated with adjuvant breast and regional nodal radiation following lumpectomy and axillary lymph node dissection for stage II invasive ductal carcinoma of the breast. She developed severe telangiectasia, fibrosis, induration, chest wall pain (with evidence of rib fractures on imaging), and painful limitation in her range of motion at the shoulder. She was subsequently found to have a likely pathogenic germline ATM gene mutation. At relapse, she elected to pursue systemic therapy alone for intracranial metastases. Cureus 2017-07-11 /pmc/articles/PMC5593749/ /pubmed/28929041 http://dx.doi.org/10.7759/cureus.1458 Text en Copyright © 2017, Dosani et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Oncology Dosani, Maryam Schrader, Kasmintan A Nichol, Alan Sun, Sophie Shenkier, Tamara Lohn, Zoe Aubertin, Gudrun Tyldesley, Scott Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions |
title | Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions |
title_full | Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions |
title_fullStr | Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions |
title_full_unstemmed | Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions |
title_short | Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions |
title_sort | severe late toxicity after adjuvant breast radiotherapy in a patient with a germline ataxia telangiectasia mutated gene: future treatment decisions |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593749/ https://www.ncbi.nlm.nih.gov/pubmed/28929041 http://dx.doi.org/10.7759/cureus.1458 |
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