Cargando…

Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH

Efficient interventions to reduce blood triglycerides are few; newer and more tolerable intervention targets are needed. Understanding the molecular mechanisms underlying blood triglyceride levels variation is key to identifying new therapies. To explore the role of epigenetic mechanisms on triglyce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Truong, Vinh, Huang, Siying, Dennis, Jessica, Lemire, Mathieu, Zwingerman, Nora, Aïssi, Dylan, Kassam, Irfahan, Perret, Claire, Wells, Philip, Morange, Pierre-Emmanuel, Wilson, Michael, Trégouët, David-Alexandre, Gagnon, France
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593822/ https://www.ncbi.nlm.nih.gov/pubmed/28894120 http://dx.doi.org/10.1038/s41598-017-09552-z

Ejemplares similares

Sex-specific effect of CPB2 Ala147Thr but not Thr325Ile variants on the risk of venous thrombosis: A comprehensive meta-analysis
por: Zwingerman, Nora, et al.
Publicado: (2017)

Genome-Wide Investigation of DNA Methylation Marks Associated with FV Leiden Mutation
por: Aïssi, Dylan, et al.
Publicado: (2014)

Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci
por: Lemire, Mathieu, et al.
Publicado: (2015)

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer
por: Possemato, Richard, et al.
Publicado: (2011)

Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver
por: Chen, Hong, et al.
Publicado: (2022)

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate
por: Pacold, Michael E., et al.
Publicado: (2016)

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
por: Reid, Michael A., et al.
Publicado: (2018)

Characterization of ETFDH and PHGDH Mutations in a Patient with Mild Glutaric Aciduria Type II and Serine Deficiency
por: Ali, Amanat, et al.
Publicado: (2021)

Microarray data on altered transcriptional program of Phgdh-deficient mouse embryonic fibroblasts caused by ʟ-serine depletion
por: Hamano, Momoko, et al.
Publicado: (2016)

PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma
por: Wang, Kui, et al.
Publicado: (2023)

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer
por: Unterlass, Judith E., et al.
Publicado: (2016)

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis
por: Sun, Shengbai, et al.
Publicado: (2021)

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
por: Wu, Yu-Qing, et al.
Publicado: (2023)

Increased PHGDH expression promotes aberrant melanin accumulation
por: Mattaini, Katherine R., et al.
Publicado: (2019)

Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer
por: Jia, Xiao-qin, et al.
Publicado: (2016)

PHGDH as a mechanism for resistance in metabolically-driven cancers
por: Rathore, Richa, et al.
Publicado: (2020)

Multi-omics Analysis of the Role of PHGDH in Colon Cancer
por: Dai, Zhihui, et al.
Publicado: (2023)

The autosomal genetic control of sexually dimorphic traits in humans is largely the same across the sexes
por: Kassam, Irfahan, et al.
Publicado: (2016)

Successful identification of rare variants using oligogenic segregation analysis as a prioritizing tool for whole-exome sequencing studies
por: Gagnon, France, et al.
Publicado: (2011)

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
por: Kang, Yun Pyo, et al.
Publicado: (2020)

Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels
por: Antoni, Guillemette, et al.
Publicado: (2011)

Down regulating PHGDH affects the lactate production of sertoli cells in varicocele
por: Guo, Wen-bin, et al.
Publicado: (2020)

Dimerization of PHGDH via the catalytic unit is essential for its enzymatic function
por: Xu, Hanyu, et al.
Publicado: (2021)

ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC
por: Wang, Huihui, et al.
Publicado: (2023)

Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)
por: Spillier, Quentin, et al.
Publicado: (2020)

Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling
por: Chen, Chen, et al.
Publicado: (2022)

PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells
por: Bi, Fangfang, et al.
Publicado: (2021)

Comprehensive analysis of PHGDH for predicting prognosis and immunotherapy response in patients with endometrial carcinoma
por: Zhang, He, et al.
Publicado: (2023)

Common and Rare 5′UTR Variants Altering Upstream Open Reading Frames in Cardiovascular Genomics
por: Soukarieh, Omar, et al.
Publicado: (2022)

High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer()
por: Zhu, Jinhong, et al.
Publicado: (2016)

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
por: D’Avola, Annalisa, et al.
Publicado: (2022)

Corrigendum: PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells
por: Bi, Fangfang, et al.
Publicado: (2022)

Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment
por: Sadiqa, Ayesha, et al.
Publicado: (2022)

Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC
por: Wang, Kaixuan, et al.
Publicado: (2023)

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)
por: Unterlass, Judith E., et al.
Publicado: (2017)

The Global mRNA Expression Profiles of Inhibiting PHGDH Induced Cisplatin Resistance in Gastric Cancer
por: Pan, Kailing, et al.
Publicado: (2022)

Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer
por: Zhu, Hongwen, et al.
Publicado: (2023)

eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation
por: Zhang, Yaguang, et al.
Publicado: (2023)

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer
por: Shen, Liliang, et al.
Publicado: (2022)

Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation
por: Yoshino, Hirofumi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r7vq2u4kitp2onecnrpmr8nd2k