D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation

The prevalence of chronic kidney disease (CKD), characterized by progressive renal dysfunction with tubulointerstitial fibrosis, is increasing because of societal aging. Uremic toxins, accumulated during renal dysfunction, cause kidney damage, leading to renal deterioration. A recent metabolomic ana...

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Detalles Bibliográficos
Autores principales: Okada, Akira, Nangaku, Masaomi, Jao, Tzu-Ming, Maekawa, Hiroshi, Ishimono, Yu, Kawakami, Takahisa, Inagi, Reiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593843/
https://www.ncbi.nlm.nih.gov/pubmed/28894140
http://dx.doi.org/10.1038/s41598-017-11049-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593843/
https://www.ncbi.nlm.nih.gov/pubmed/28894140
http://dx.doi.org/10.1038/s41598-017-11049-8

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