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Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters
Sound and timely microbial gut colonization completes newborn’s healthy metabolic programming and manifests in infant appropriate growth and weight development. Feces, collected at 3, 30, and 90 days after birth from 60 breastfed Slovenian newborns, was submitted to microbial DNA extraction and qPCR...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593852/ https://www.ncbi.nlm.nih.gov/pubmed/28894126 http://dx.doi.org/10.1038/s41598-017-10244-x |
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author | Obermajer, Tanja Grabnar, Iztok Benedik, Evgen Tušar, Tina Robič Pikel, Tatjana Fidler Mis, Nataša Bogovič Matijašić, Bojana Rogelj, Irena |
author_facet | Obermajer, Tanja Grabnar, Iztok Benedik, Evgen Tušar, Tina Robič Pikel, Tatjana Fidler Mis, Nataša Bogovič Matijašić, Bojana Rogelj, Irena |
author_sort | Obermajer, Tanja |
collection | PubMed |
description | Sound and timely microbial gut colonization completes newborn’s healthy metabolic programming and manifests in infant appropriate growth and weight development. Feces, collected at 3, 30, and 90 days after birth from 60 breastfed Slovenian newborns, was submitted to microbial DNA extraction and qPCR quantification of selected gut associated taxa. Multivariate regression analysis was applied to evaluate microbial dynamics with respect to infant demographic, environmental, clinical characteristics and first year growth data. Early microbial variability was marked by the proportion of Bacilli, but diminished and converged in later samples, as bifidobacteria started to prevail. The first month proportions of enterococci were associated with maternity hospital locality and supplementation of breastfeeding with formulae, while Enterococcus faecalis proportion reflected the mode of delivery. Group Bacteroides-Prevotella proportion was associated with infant weight and ponderal index at first month. Infant mixed feeding pattern and health issues within the first month revealed the most profound and extended microbial perturbations. Our findings raise concerns over the ability of the early feeding supplementation to emulate and support the gut microbiota in a way similar to the exclusively breastfed infants. Additionally, practicing supplementation beyond the first month also manifested in higher first year weight and weight gain Z-score. |
format | Online Article Text |
id | pubmed-5593852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55938522017-09-13 Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters Obermajer, Tanja Grabnar, Iztok Benedik, Evgen Tušar, Tina Robič Pikel, Tatjana Fidler Mis, Nataša Bogovič Matijašić, Bojana Rogelj, Irena Sci Rep Article Sound and timely microbial gut colonization completes newborn’s healthy metabolic programming and manifests in infant appropriate growth and weight development. Feces, collected at 3, 30, and 90 days after birth from 60 breastfed Slovenian newborns, was submitted to microbial DNA extraction and qPCR quantification of selected gut associated taxa. Multivariate regression analysis was applied to evaluate microbial dynamics with respect to infant demographic, environmental, clinical characteristics and first year growth data. Early microbial variability was marked by the proportion of Bacilli, but diminished and converged in later samples, as bifidobacteria started to prevail. The first month proportions of enterococci were associated with maternity hospital locality and supplementation of breastfeeding with formulae, while Enterococcus faecalis proportion reflected the mode of delivery. Group Bacteroides-Prevotella proportion was associated with infant weight and ponderal index at first month. Infant mixed feeding pattern and health issues within the first month revealed the most profound and extended microbial perturbations. Our findings raise concerns over the ability of the early feeding supplementation to emulate and support the gut microbiota in a way similar to the exclusively breastfed infants. Additionally, practicing supplementation beyond the first month also manifested in higher first year weight and weight gain Z-score. Nature Publishing Group UK 2017-09-11 /pmc/articles/PMC5593852/ /pubmed/28894126 http://dx.doi.org/10.1038/s41598-017-10244-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Obermajer, Tanja Grabnar, Iztok Benedik, Evgen Tušar, Tina Robič Pikel, Tatjana Fidler Mis, Nataša Bogovič Matijašić, Bojana Rogelj, Irena Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters |
title | Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters |
title_full | Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters |
title_fullStr | Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters |
title_full_unstemmed | Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters |
title_short | Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters |
title_sort | microbes in infant gut development: placing abundance within environmental, clinical and growth parameters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593852/ https://www.ncbi.nlm.nih.gov/pubmed/28894126 http://dx.doi.org/10.1038/s41598-017-10244-x |
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