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Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism

In 2002, the plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) was introduced in the European market as a substitute for endocrine-disrupting phthalates. We found that in utero exposure of rats to DINCH from gestational day 14 until parturition affected reproductive organ physio...

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Autores principales: Campioli, Enrico, Lee, Sunghoon, Lau, Matthew, Marques, Lucas, Papadopoulos, Vassilios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593853/
https://www.ncbi.nlm.nih.gov/pubmed/28894178
http://dx.doi.org/10.1038/s41598-017-11325-7
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author Campioli, Enrico
Lee, Sunghoon
Lau, Matthew
Marques, Lucas
Papadopoulos, Vassilios
author_facet Campioli, Enrico
Lee, Sunghoon
Lau, Matthew
Marques, Lucas
Papadopoulos, Vassilios
author_sort Campioli, Enrico
collection PubMed
description In 2002, the plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) was introduced in the European market as a substitute for endocrine-disrupting phthalates. We found that in utero exposure of rats to DINCH from gestational day 14 until parturition affected reproductive organ physiology and reduced circulating testosterone levels at post-natal day 60, indicating a long-term effect on Leydig cells of the testis. Metabolically, animals exhibited randomly increased serum glucose concentrations not associated with impaired glucose utilization. Analysis of liver markers in the serum showed a hepatic effect; e.g. reduced bilirubin levels and albumin/globulin ratio. At post-natal day 200, random appearance of testicular atrophy was noted in exposed offspring, and limited changes in other reproductive parameters were observed. In conclusion, DINCH exposure appears to directly affect Leydig cell function, likely causing premature aging of the testes and impaired liver metabolic capacity. These effects might be attenuated with physiologic aging.
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spelling pubmed-55938532017-09-13 Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism Campioli, Enrico Lee, Sunghoon Lau, Matthew Marques, Lucas Papadopoulos, Vassilios Sci Rep Article In 2002, the plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) was introduced in the European market as a substitute for endocrine-disrupting phthalates. We found that in utero exposure of rats to DINCH from gestational day 14 until parturition affected reproductive organ physiology and reduced circulating testosterone levels at post-natal day 60, indicating a long-term effect on Leydig cells of the testis. Metabolically, animals exhibited randomly increased serum glucose concentrations not associated with impaired glucose utilization. Analysis of liver markers in the serum showed a hepatic effect; e.g. reduced bilirubin levels and albumin/globulin ratio. At post-natal day 200, random appearance of testicular atrophy was noted in exposed offspring, and limited changes in other reproductive parameters were observed. In conclusion, DINCH exposure appears to directly affect Leydig cell function, likely causing premature aging of the testes and impaired liver metabolic capacity. These effects might be attenuated with physiologic aging. Nature Publishing Group UK 2017-09-11 /pmc/articles/PMC5593853/ /pubmed/28894178 http://dx.doi.org/10.1038/s41598-017-11325-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Campioli, Enrico
Lee, Sunghoon
Lau, Matthew
Marques, Lucas
Papadopoulos, Vassilios
Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism
title Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism
title_full Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism
title_fullStr Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism
title_full_unstemmed Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism
title_short Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism
title_sort effect of prenatal dinch plasticizer exposure on rat offspring testicular function and metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593853/
https://www.ncbi.nlm.nih.gov/pubmed/28894178
http://dx.doi.org/10.1038/s41598-017-11325-7
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