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Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients

Reduced biodiversity and increased representation of opportunistic pathogens are typical features of gut microbiota composition in aging. Few studies have investigated their correlation with polypharmacy, multimorbidity and frailty. To assess it, we analyzed the fecal microbiota from 76 inpatients,...

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Autores principales: Ticinesi, Andrea, Milani, Christian, Lauretani, Fulvio, Nouvenne, Antonio, Mancabelli, Leonardo, Lugli, Gabriele Andrea, Turroni, Francesca, Duranti, Sabrina, Mangifesta, Marta, Viappiani, Alice, Ferrario, Chiara, Maggio, Marcello, Ventura, Marco, Meschi, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593887/
https://www.ncbi.nlm.nih.gov/pubmed/28894183
http://dx.doi.org/10.1038/s41598-017-10734-y
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author Ticinesi, Andrea
Milani, Christian
Lauretani, Fulvio
Nouvenne, Antonio
Mancabelli, Leonardo
Lugli, Gabriele Andrea
Turroni, Francesca
Duranti, Sabrina
Mangifesta, Marta
Viappiani, Alice
Ferrario, Chiara
Maggio, Marcello
Ventura, Marco
Meschi, Tiziana
author_facet Ticinesi, Andrea
Milani, Christian
Lauretani, Fulvio
Nouvenne, Antonio
Mancabelli, Leonardo
Lugli, Gabriele Andrea
Turroni, Francesca
Duranti, Sabrina
Mangifesta, Marta
Viappiani, Alice
Ferrario, Chiara
Maggio, Marcello
Ventura, Marco
Meschi, Tiziana
author_sort Ticinesi, Andrea
collection PubMed
description Reduced biodiversity and increased representation of opportunistic pathogens are typical features of gut microbiota composition in aging. Few studies have investigated their correlation with polypharmacy, multimorbidity and frailty. To assess it, we analyzed the fecal microbiota from 76 inpatients, aged 83 ± 8. Microbiome biodiversity (Chao1 index) and relative abundance of individual bacterial taxa were determined by next-generation 16S rRNA microbial profiling. Their correlation with number of drugs, and indexes of multimorbidity and frailty were verified using multivariate linear regression models. The impact of gut microbiota biodiversity on mortality, rehospitalizations and incident sepsis was also assessed after a 2-year follow-up, using Cox regression analysis. We found a significant negative correlation between the number of drugs and Chao1 Index at multivariate analysis. The number of drugs was associated with the average relative abundance of 15 taxa. The drug classes exhibiting the strongest association with single taxa abundance were proton pump inhibitors, antidepressants and antipsychotics. Conversely, frailty and multimorbidity were not significantly associated with gut microbiota biodiversity. Very low Chao1 index was also a significant predictor of mortality, but not of rehospitalizations and sepsis, at follow-up. In aging, polypharmacy may thus represent a determinant of gut microbiota composition, with detrimental clinical consequences.
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spelling pubmed-55938872017-09-13 Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients Ticinesi, Andrea Milani, Christian Lauretani, Fulvio Nouvenne, Antonio Mancabelli, Leonardo Lugli, Gabriele Andrea Turroni, Francesca Duranti, Sabrina Mangifesta, Marta Viappiani, Alice Ferrario, Chiara Maggio, Marcello Ventura, Marco Meschi, Tiziana Sci Rep Article Reduced biodiversity and increased representation of opportunistic pathogens are typical features of gut microbiota composition in aging. Few studies have investigated their correlation with polypharmacy, multimorbidity and frailty. To assess it, we analyzed the fecal microbiota from 76 inpatients, aged 83 ± 8. Microbiome biodiversity (Chao1 index) and relative abundance of individual bacterial taxa were determined by next-generation 16S rRNA microbial profiling. Their correlation with number of drugs, and indexes of multimorbidity and frailty were verified using multivariate linear regression models. The impact of gut microbiota biodiversity on mortality, rehospitalizations and incident sepsis was also assessed after a 2-year follow-up, using Cox regression analysis. We found a significant negative correlation between the number of drugs and Chao1 Index at multivariate analysis. The number of drugs was associated with the average relative abundance of 15 taxa. The drug classes exhibiting the strongest association with single taxa abundance were proton pump inhibitors, antidepressants and antipsychotics. Conversely, frailty and multimorbidity were not significantly associated with gut microbiota biodiversity. Very low Chao1 index was also a significant predictor of mortality, but not of rehospitalizations and sepsis, at follow-up. In aging, polypharmacy may thus represent a determinant of gut microbiota composition, with detrimental clinical consequences. Nature Publishing Group UK 2017-09-11 /pmc/articles/PMC5593887/ /pubmed/28894183 http://dx.doi.org/10.1038/s41598-017-10734-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ticinesi, Andrea
Milani, Christian
Lauretani, Fulvio
Nouvenne, Antonio
Mancabelli, Leonardo
Lugli, Gabriele Andrea
Turroni, Francesca
Duranti, Sabrina
Mangifesta, Marta
Viappiani, Alice
Ferrario, Chiara
Maggio, Marcello
Ventura, Marco
Meschi, Tiziana
Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients
title Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients
title_full Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients
title_fullStr Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients
title_full_unstemmed Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients
title_short Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients
title_sort gut microbiota composition is associated with polypharmacy in elderly hospitalized patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593887/
https://www.ncbi.nlm.nih.gov/pubmed/28894183
http://dx.doi.org/10.1038/s41598-017-10734-y
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