A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure

A green electrodeposition method was firstly employed for the synthesis of round hairbrush-like gold nanostructure in the presence of cadaverine as a size and shape directing additive. The nanostructure which comprised of arrays of nanospindles was then applied as a transducer to fabricate a signal-...

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Autores principales: Sattarahmady, Naghmeh, Rahi, Amid, Heli, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593896/
https://www.ncbi.nlm.nih.gov/pubmed/28894225
http://dx.doi.org/10.1038/s41598-017-11680-5
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author Sattarahmady, Naghmeh
Rahi, Amid
Heli, Hossein
author_facet Sattarahmady, Naghmeh
Rahi, Amid
Heli, Hossein
author_sort Sattarahmady, Naghmeh
collection PubMed
description A green electrodeposition method was firstly employed for the synthesis of round hairbrush-like gold nanostructure in the presence of cadaverine as a size and shape directing additive. The nanostructure which comprised of arrays of nanospindles was then applied as a transducer to fabricate a signal-on built in-marker electrochemical aptasensor for the detection of human prostate-specific antigen (PSA). The aptasensor detected PSA with a linear concentration range of 0.125 to 128 ng mL(−1) and a limit of detection of 50 pg mL(−1). The aptasensor was then successfully applied to detect PSA in the blood serum samples of healthy and patient persons.
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spelling pubmed-55938962017-09-13 A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure Sattarahmady, Naghmeh Rahi, Amid Heli, Hossein Sci Rep Article A green electrodeposition method was firstly employed for the synthesis of round hairbrush-like gold nanostructure in the presence of cadaverine as a size and shape directing additive. The nanostructure which comprised of arrays of nanospindles was then applied as a transducer to fabricate a signal-on built in-marker electrochemical aptasensor for the detection of human prostate-specific antigen (PSA). The aptasensor detected PSA with a linear concentration range of 0.125 to 128 ng mL(−1) and a limit of detection of 50 pg mL(−1). The aptasensor was then successfully applied to detect PSA in the blood serum samples of healthy and patient persons. Nature Publishing Group UK 2017-09-11 /pmc/articles/PMC5593896/ /pubmed/28894225 http://dx.doi.org/10.1038/s41598-017-11680-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sattarahmady, Naghmeh
Rahi, Amid
Heli, Hossein
A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure
title A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure
title_full A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure
title_fullStr A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure
title_full_unstemmed A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure
title_short A signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure
title_sort signal-on built in-marker electrochemical aptasensor for human prostate-specific antigen based on a hairbrush-like gold nanostructure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593896/
https://www.ncbi.nlm.nih.gov/pubmed/28894225
http://dx.doi.org/10.1038/s41598-017-11680-5
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