5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR

5-methoxytryptophan (5-MTP) is a newly discovered tryptophan metabolite which controls stress-induced inflammatory signals. To determine whether 5-MTP protects against stress-induced mesenchymal stem cell (MSC) senescence, we incubated bone marrow-derived MSC (BM-MSC) in high-glucose medium or regul...

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Detalles Bibliográficos
Autores principales: Chang, Tzu-Ching, Hsu, Min-Fen, Shih, Chiu-Yueh, Wu, Kenneth K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593915/
https://www.ncbi.nlm.nih.gov/pubmed/28894133
http://dx.doi.org/10.1038/s41598-017-11077-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593915/
https://www.ncbi.nlm.nih.gov/pubmed/28894133
http://dx.doi.org/10.1038/s41598-017-11077-4

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