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The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3

Long QT Syndrome 3 (LQTS3) arises from gain-of-function Na(v)1.5 mutations, prolonging action potential repolarisation and electrocardiographic (ECG) QT interval, associated with increased age-dependent risk for major arrhythmic events, and paradoxical responses to β-adrenergic agents. We investigat...

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Detalles Bibliográficos
Autores principales:	Chadda, Karan R., Ahmad, Shiraz, Valli, Haseeb, den Uijl, Ingrid, Al-Hadithi, Ali BAK, Salvage, Samantha C., Grace, Andrew A., Huang, Christopher L.-H., Jeevaratnam, Kamalan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593918/ https://www.ncbi.nlm.nih.gov/pubmed/28894151 http://dx.doi.org/10.1038/s41598-017-11210-3

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