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Generation of a new mouse model of glaucoma characterized by reduced expression of the AP-2β and AP-2δ proteins
We generated 6 transgenic lines with insertion of an expression plasmid for the R883/M xanthine dehydrogenase (XDH) mutant protein. Approximately 20% of the animals deriving from one of the transgenic lines show ocular abnormalities and an increase in intra-ocular pressure which are consistent with...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593953/ https://www.ncbi.nlm.nih.gov/pubmed/28894266 http://dx.doi.org/10.1038/s41598-017-11752-6 |