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KDM4A regulates HIF-1 levels through H3K9me3

Regions of hypoxia (low oxygen) occur in most solid tumours and cells in these areas are the most aggressive and therapy resistant. In response to decreased oxygen, extensive changes in gene expression mediated by Hypoxia-Inducible Factors (HIFs) contribute significantly to the aggressive hypoxic tu...

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Detalles Bibliográficos
Autores principales:	Dobrynin, Grzegorz, McAllister, Tom E., Leszczynska, Katarzyna B., Ramachandran, Shaliny, Krieg, Adam J., Kawamura, Akane, Hammond, Ester M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593970/ https://www.ncbi.nlm.nih.gov/pubmed/28894274 http://dx.doi.org/10.1038/s41598-017-11658-3

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