Onset of disorder and protein aggregation due to oxidation-induced intermolecular disulfide bonds: case study of RRM2 domain from TDP-43

We have investigated the behavior of second RNA-recognition motif (RRM2) of neuropathological protein TDP43 under the effect of oxidative stress as modeled in vitro. Toward this end we have used the specially adapted version of H/D exchange experiment, NMR relaxation and diffusion measurements, dyna...

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Detalles Bibliográficos
Autores principales: Rabdano, Sevastyan O., Izmailov, Sergei A., Luzik, Dmitrii A., Groves, Adam, Podkorytov, Ivan S., Skrynnikov, Nikolai R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593996/
https://www.ncbi.nlm.nih.gov/pubmed/28894122
http://dx.doi.org/10.1038/s41598-017-10574-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593996/
https://www.ncbi.nlm.nih.gov/pubmed/28894122
http://dx.doi.org/10.1038/s41598-017-10574-w

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