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Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia

Adrenocortical hormone excess, due to primary aldosteronism (PA) or hypercortisolemia, causes hypertension and cardiovascular complications. In PA, hypomethylation of aldosterone synthase (CYP11B2) is associated with aldosterone overproduction. However, in hypercortisolemia, the role of DNA methylat...

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Detalles Bibliográficos
Autores principales:	Kometani, Mitsuhiro, Yoneda, Takashi, Demura, Masashi, Koide, Hiroshi, Nishimoto, Koshiro, Mukai, Kuniaki, Gomez-Sanchez, Celso E., Akagi, Tadayuki, Yokota, Takashi, Horike, Shin-ichi, Karashima, Shigehiro, Miyamori, Isamu, Yamagishi, Masakazu, Takeda, Yoshiyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594008/ https://www.ncbi.nlm.nih.gov/pubmed/28894201 http://dx.doi.org/10.1038/s41598-017-11435-2

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