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Acid Stress Response Mechanisms of Group B Streptococci

Group B streptococcus (GBS) is a leading cause of neonatal mortality and morbidity in the United States and Europe. It is part of the vaginal microbiota in up to 30% of pregnant women and can be passed on to the newborn through perinatal transmission. GBS has the ability to survive in multiple diffe...

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Autores principales: Shabayek, Sarah, Spellerberg, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594096/
https://www.ncbi.nlm.nih.gov/pubmed/28936424
http://dx.doi.org/10.3389/fcimb.2017.00395
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author Shabayek, Sarah
Spellerberg, Barbara
author_facet Shabayek, Sarah
Spellerberg, Barbara
author_sort Shabayek, Sarah
collection PubMed
description Group B streptococcus (GBS) is a leading cause of neonatal mortality and morbidity in the United States and Europe. It is part of the vaginal microbiota in up to 30% of pregnant women and can be passed on to the newborn through perinatal transmission. GBS has the ability to survive in multiple different host niches. The pathophysiology of this bacterium reveals an outstanding ability to withstand varying pH fluctuations of the surrounding environments inside the human host. GBS host pathogen interations include colonization of the acidic vaginal mucosa, invasion of the neutral human blood or amniotic fluid, breaching of the blood brain barrier as well as survival within the acidic phagolysosomal compartment of macrophages. However, investigations on GBS responses to acid stress are limited. Technologies, such as whole genome sequencing, genome-wide transcription and proteome mapping facilitate large scale identification of genes and proteins. Mechanisms enabling GBS to cope with acid stress have mainly been studied through these techniques and are summarized in the current review
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spelling pubmed-55940962017-09-21 Acid Stress Response Mechanisms of Group B Streptococci Shabayek, Sarah Spellerberg, Barbara Front Cell Infect Microbiol Microbiology Group B streptococcus (GBS) is a leading cause of neonatal mortality and morbidity in the United States and Europe. It is part of the vaginal microbiota in up to 30% of pregnant women and can be passed on to the newborn through perinatal transmission. GBS has the ability to survive in multiple different host niches. The pathophysiology of this bacterium reveals an outstanding ability to withstand varying pH fluctuations of the surrounding environments inside the human host. GBS host pathogen interations include colonization of the acidic vaginal mucosa, invasion of the neutral human blood or amniotic fluid, breaching of the blood brain barrier as well as survival within the acidic phagolysosomal compartment of macrophages. However, investigations on GBS responses to acid stress are limited. Technologies, such as whole genome sequencing, genome-wide transcription and proteome mapping facilitate large scale identification of genes and proteins. Mechanisms enabling GBS to cope with acid stress have mainly been studied through these techniques and are summarized in the current review Frontiers Media S.A. 2017-09-07 /pmc/articles/PMC5594096/ /pubmed/28936424 http://dx.doi.org/10.3389/fcimb.2017.00395 Text en Copyright © 2017 Shabayek and Spellerberg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Shabayek, Sarah
Spellerberg, Barbara
Acid Stress Response Mechanisms of Group B Streptococci
title Acid Stress Response Mechanisms of Group B Streptococci
title_full Acid Stress Response Mechanisms of Group B Streptococci
title_fullStr Acid Stress Response Mechanisms of Group B Streptococci
title_full_unstemmed Acid Stress Response Mechanisms of Group B Streptococci
title_short Acid Stress Response Mechanisms of Group B Streptococci
title_sort acid stress response mechanisms of group b streptococci
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594096/
https://www.ncbi.nlm.nih.gov/pubmed/28936424
http://dx.doi.org/10.3389/fcimb.2017.00395
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