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Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs
Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594098/ https://www.ncbi.nlm.nih.gov/pubmed/28936190 http://dx.doi.org/10.3389/fpsyg.2017.01520 |
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author | Kubinyi, Enikő Bence, Melinda Koller, Dora Wan, Michele Pergel, Eniko Ronai, Zsolt Sasvari-Szekely, Maria Miklósi, Ádám |
author_facet | Kubinyi, Enikő Bence, Melinda Koller, Dora Wan, Michele Pergel, Eniko Ronai, Zsolt Sasvari-Szekely, Maria Miklósi, Ádám |
author_sort | Kubinyi, Enikő |
collection | PubMed |
description | Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests that although broad traits are affected by genetic variability, the specific links between alleles and behavioral variables might be breed-specific. In the current study, we found that Siberian huskies with the A allele approached a friendly unfamiliar woman less frequently in a greeting test, which indicates that certain polymorphisms are related to human directed behavior, but that the relationship patterns between polymorphisms and behavioral phenotypes differ between populations. This finding was further supported by our next investigation. According to primate studies, endogenous opioid peptide (e.g., endorphins) receptor genes have also been implicated in social relationships. Therefore, we examined the rs21912990 of the OPRM1 gene. Firstly, we found that the allele frequencies of Siberian huskies and gray wolves were similar, but differed from that of Border collies and German shepherd dogs, which might reflect their genetic relationship. Secondly, we detected significant associations between the OPRM1 SNP and greeting behavior among German shepherd dogs and a trend in Border collies, but we could not detect an association in Siberian huskies. Although our results with OXTR and OPRM1 gene variants should be regarded as preliminary due to the relatively low sample size, they suggest that (1) OXTR and OPRM1 gene variants in dogs affect human-directed social behavior and (2) their effects differ between breeds. |
format | Online Article Text |
id | pubmed-5594098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55940982017-09-21 Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs Kubinyi, Enikő Bence, Melinda Koller, Dora Wan, Michele Pergel, Eniko Ronai, Zsolt Sasvari-Szekely, Maria Miklósi, Ádám Front Psychol Psychology Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests that although broad traits are affected by genetic variability, the specific links between alleles and behavioral variables might be breed-specific. In the current study, we found that Siberian huskies with the A allele approached a friendly unfamiliar woman less frequently in a greeting test, which indicates that certain polymorphisms are related to human directed behavior, but that the relationship patterns between polymorphisms and behavioral phenotypes differ between populations. This finding was further supported by our next investigation. According to primate studies, endogenous opioid peptide (e.g., endorphins) receptor genes have also been implicated in social relationships. Therefore, we examined the rs21912990 of the OPRM1 gene. Firstly, we found that the allele frequencies of Siberian huskies and gray wolves were similar, but differed from that of Border collies and German shepherd dogs, which might reflect their genetic relationship. Secondly, we detected significant associations between the OPRM1 SNP and greeting behavior among German shepherd dogs and a trend in Border collies, but we could not detect an association in Siberian huskies. Although our results with OXTR and OPRM1 gene variants should be regarded as preliminary due to the relatively low sample size, they suggest that (1) OXTR and OPRM1 gene variants in dogs affect human-directed social behavior and (2) their effects differ between breeds. Frontiers Media S.A. 2017-09-07 /pmc/articles/PMC5594098/ /pubmed/28936190 http://dx.doi.org/10.3389/fpsyg.2017.01520 Text en Copyright © 2017 Kubinyi, Bence, Koller, Wan, Pergel, Ronai, Sasvari-Szekely and Miklósi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Kubinyi, Enikő Bence, Melinda Koller, Dora Wan, Michele Pergel, Eniko Ronai, Zsolt Sasvari-Szekely, Maria Miklósi, Ádám Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs |
title | Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs |
title_full | Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs |
title_fullStr | Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs |
title_full_unstemmed | Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs |
title_short | Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs |
title_sort | oxytocin and opioid receptor gene polymorphisms associated with greeting behavior in dogs |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594098/ https://www.ncbi.nlm.nih.gov/pubmed/28936190 http://dx.doi.org/10.3389/fpsyg.2017.01520 |
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