Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks, leading to cell lethality. To understand the molecular mechanisms underlying this process, we isolated Xenopus laevis Brca2. We demonstrated that Brca2 protein prevents single-stranded DNA gap accumulation at replic...

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Detalles Bibliográficos
Autores principales: Kolinjivadi, Arun Mouli, Sannino, Vincenzo, De Antoni, Anna, Zadorozhny, Karina, Kilkenny, Mairi, Técher, Hervé, Baldi, Giorgio, Shen, Rong, Ciccia, Alberto, Pellegrini, Luca, Krejci, Lumir, Costanzo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594205/
https://www.ncbi.nlm.nih.gov/pubmed/28757209
http://dx.doi.org/10.1016/j.molcel.2017.07.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594205/
https://www.ncbi.nlm.nih.gov/pubmed/28757209
http://dx.doi.org/10.1016/j.molcel.2017.07.001

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