5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m(5)C reader

5-methylcytosine (m(5)C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown. Here, we reveal that m(5)C modification is enriched in CG-rich regions and in regi...

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Detalles Bibliográficos
Autores principales: Yang, Xin, Yang, Ying, Sun, Bao-Fa, Chen, Yu-Sheng, Xu, Jia-Wei, Lai, Wei-Yi, Li, Ang, Wang, Xing, Bhattarai, Devi Prasad, Xiao, Wen, Sun, Hui-Ying, Zhu, Qin, Ma, Hai-Li, Adhikari, Samir, Sun, Min, Hao, Ya-Juan, Zhang, Bing, Huang, Chun-Min, Huang, Niu, Jiang, Gui-Bin, Zhao, Yong-Liang, Wang, Hai-Lin, Sun, Ying-Pu, Yang, Yun-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594206/
https://www.ncbi.nlm.nih.gov/pubmed/28418038
http://dx.doi.org/10.1038/cr.2017.55

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