Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer

TMEM16A (known as anoctamin 1) Ca(2+)-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification. TMEM16A expression is also controlled in many cancer cells via transcriptional regulation, epigen...

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Detalles Bibliográficos
Autores principales: Wang, Hui, Zou, Liang, Ma, Ke, Yu, Jiankun, Wu, Huizhe, Wei, Minjie, Xiao, Qinghuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594453/
https://www.ncbi.nlm.nih.gov/pubmed/28893247
http://dx.doi.org/10.1186/s12943-017-0720-x

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