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Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients

BACKGROUND: Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional...

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Autores principales: You, Hong, Zhang, Tong, Feng, Wen, Gai, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594579/
https://www.ncbi.nlm.nih.gov/pubmed/28893239
http://dx.doi.org/10.1186/s12906-017-1964-0
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author You, Hong
Zhang, Tong
Feng, Wen
Gai, Yun
author_facet You, Hong
Zhang, Tong
Feng, Wen
Gai, Yun
author_sort You, Hong
collection PubMed
description BACKGROUND: Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) body constitution and serum cytokines, and whether body constitution could independently predict diabetes in IGR subjects. METHOD: Patients with IGR (n = 306) received a blood test and their body constitution type was assessed using a body constitution questionnaire (BCQ). Serum levels of cytokines were measured by ELISA. Patients were followed up for at least three years, and their status of diabetes were recorded. Multivariate logistic regression was used to estimate odds ratios (ORs) of diabetes for body constitution. RESULTS: Phlegm-damp, Damp-heat and Qi-deficiency were three most common unbanlenced constitutions among IGR subjects. Phlegm-damp and Damp-heat constitution subjects showed higher serum levels of interleukin 6 (IL-6), tumour necrosis factor-α (TNF-α), leptin and lower serum levels of adiponectin (P<0.05). Qi-deficiency constitution subjects showed higher serum levels of leptin and lower serum levels of adiponectin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) (P<0.05). Subjects with Phlegm-damp or Damp-heat constitution demonstrated a significantly higher risk of diabetes (P<0.05). CONCLUSION: Phlegm-damp and Damp-heat TCM body constitution are strongly associated with abnormal serum cytokines, and could potentially serve as a predictor of diabetes in IGR subjects. Body constitution can help to identify IGR subjects who are at a high risk of progression to diabetes.
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spelling pubmed-55945792017-09-15 Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients You, Hong Zhang, Tong Feng, Wen Gai, Yun BMC Complement Altern Med Research Article BACKGROUND: Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) body constitution and serum cytokines, and whether body constitution could independently predict diabetes in IGR subjects. METHOD: Patients with IGR (n = 306) received a blood test and their body constitution type was assessed using a body constitution questionnaire (BCQ). Serum levels of cytokines were measured by ELISA. Patients were followed up for at least three years, and their status of diabetes were recorded. Multivariate logistic regression was used to estimate odds ratios (ORs) of diabetes for body constitution. RESULTS: Phlegm-damp, Damp-heat and Qi-deficiency were three most common unbanlenced constitutions among IGR subjects. Phlegm-damp and Damp-heat constitution subjects showed higher serum levels of interleukin 6 (IL-6), tumour necrosis factor-α (TNF-α), leptin and lower serum levels of adiponectin (P<0.05). Qi-deficiency constitution subjects showed higher serum levels of leptin and lower serum levels of adiponectin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) (P<0.05). Subjects with Phlegm-damp or Damp-heat constitution demonstrated a significantly higher risk of diabetes (P<0.05). CONCLUSION: Phlegm-damp and Damp-heat TCM body constitution are strongly associated with abnormal serum cytokines, and could potentially serve as a predictor of diabetes in IGR subjects. Body constitution can help to identify IGR subjects who are at a high risk of progression to diabetes. BioMed Central 2017-09-11 /pmc/articles/PMC5594579/ /pubmed/28893239 http://dx.doi.org/10.1186/s12906-017-1964-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
You, Hong
Zhang, Tong
Feng, Wen
Gai, Yun
Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
title Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
title_full Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
title_fullStr Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
title_full_unstemmed Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
title_short Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
title_sort association of tcm body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594579/
https://www.ncbi.nlm.nih.gov/pubmed/28893239
http://dx.doi.org/10.1186/s12906-017-1964-0
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