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The Role of Adjuvant Treatment in Patients with High-Grade Meningioma
OBJECTIVE: To investigate the efficacy of adjuvant treatment in patients with high-grade meningioma. METHODS: A retrospective analysis was performed for patients with high-grade meningioma, World Health Organization grade 2 or 3, in a single center between 2003 and 2014. The patients were reviewed a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurosurgical Society
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594630/ https://www.ncbi.nlm.nih.gov/pubmed/28881115 http://dx.doi.org/10.3340/jkns.2016.1111.009 |
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author | Cho, Minjae Joo, Jin-Deok Kim, In Ah Han, Jung Ho Oh, Chang Wan Kim, Chae-Yong |
author_facet | Cho, Minjae Joo, Jin-Deok Kim, In Ah Han, Jung Ho Oh, Chang Wan Kim, Chae-Yong |
author_sort | Cho, Minjae |
collection | PubMed |
description | OBJECTIVE: To investigate the efficacy of adjuvant treatment in patients with high-grade meningioma. METHODS: A retrospective analysis was performed for patients with high-grade meningioma, World Health Organization grade 2 or 3, in a single center between 2003 and 2014. The patients were reviewed according to age at diagnosis, sex, the location of meningioma, degree of tumor resection, histological features, and type of adjuvant treatment. These factors were analyzed by Firth logistic regression analyses. RESULTS: Fifty-three patients with high-grade meningioma were enrolled. Thirty-four patients received adjuvant treatment; conventional radiotherapy or radiosurgery. Clinical follow-up ranged from 13–113 months with a median follow-up of 35.5 months. Gross total removal (GTR), Simpson grade 1 or 2, was achieved in 29 patients and, among them, 13 patients received adjuvant treatment. In the other 24 patients with non-GTR, conventional adjuvant radiotherapy and radiosurgery were performed in 11 and 10 patients, respectively. The other 3 patients did not receive any adjuvant treatment. Radiation-related complications did not occur. Of the 53 patients, 19 patients had suffered from recurrence. The recurrence rate in the adjuvant treatment group was 23.5% (8 out of 34). On the other hand, the rate for the non-adjuvant treatment group was 57.9% (11 out of 19) (odds ratio [OR]=0.208, p=0.017). In the GTR group, the recurrence rate was 7.5% (1 out of 13) for patients with adjuvant treatment and 50% (8 out of 16) for patients without adjuvant treatment (OR=0.121, p=0.04). CONCLUSION: Adjuvant treatment appears to be safe and effective, and could lead to a lower recurrence rate in high-grade meningioma, regardless of the extent of removal. Our results might be used as a reference for making decisions when planning adjuvant treatments for patients with high-grade meningioma after surgery. |
format | Online Article Text |
id | pubmed-5594630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-55946302017-09-13 The Role of Adjuvant Treatment in Patients with High-Grade Meningioma Cho, Minjae Joo, Jin-Deok Kim, In Ah Han, Jung Ho Oh, Chang Wan Kim, Chae-Yong J Korean Neurosurg Soc Clinical Article OBJECTIVE: To investigate the efficacy of adjuvant treatment in patients with high-grade meningioma. METHODS: A retrospective analysis was performed for patients with high-grade meningioma, World Health Organization grade 2 or 3, in a single center between 2003 and 2014. The patients were reviewed according to age at diagnosis, sex, the location of meningioma, degree of tumor resection, histological features, and type of adjuvant treatment. These factors were analyzed by Firth logistic regression analyses. RESULTS: Fifty-three patients with high-grade meningioma were enrolled. Thirty-four patients received adjuvant treatment; conventional radiotherapy or radiosurgery. Clinical follow-up ranged from 13–113 months with a median follow-up of 35.5 months. Gross total removal (GTR), Simpson grade 1 or 2, was achieved in 29 patients and, among them, 13 patients received adjuvant treatment. In the other 24 patients with non-GTR, conventional adjuvant radiotherapy and radiosurgery were performed in 11 and 10 patients, respectively. The other 3 patients did not receive any adjuvant treatment. Radiation-related complications did not occur. Of the 53 patients, 19 patients had suffered from recurrence. The recurrence rate in the adjuvant treatment group was 23.5% (8 out of 34). On the other hand, the rate for the non-adjuvant treatment group was 57.9% (11 out of 19) (odds ratio [OR]=0.208, p=0.017). In the GTR group, the recurrence rate was 7.5% (1 out of 13) for patients with adjuvant treatment and 50% (8 out of 16) for patients without adjuvant treatment (OR=0.121, p=0.04). CONCLUSION: Adjuvant treatment appears to be safe and effective, and could lead to a lower recurrence rate in high-grade meningioma, regardless of the extent of removal. Our results might be used as a reference for making decisions when planning adjuvant treatments for patients with high-grade meningioma after surgery. Korean Neurosurgical Society 2017-09 2017-08-29 /pmc/articles/PMC5594630/ /pubmed/28881115 http://dx.doi.org/10.3340/jkns.2016.1111.009 Text en Copyright © 2017 The Korean Neurosurgical Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Article Cho, Minjae Joo, Jin-Deok Kim, In Ah Han, Jung Ho Oh, Chang Wan Kim, Chae-Yong The Role of Adjuvant Treatment in Patients with High-Grade Meningioma |
title | The Role of Adjuvant Treatment in Patients with High-Grade Meningioma |
title_full | The Role of Adjuvant Treatment in Patients with High-Grade Meningioma |
title_fullStr | The Role of Adjuvant Treatment in Patients with High-Grade Meningioma |
title_full_unstemmed | The Role of Adjuvant Treatment in Patients with High-Grade Meningioma |
title_short | The Role of Adjuvant Treatment in Patients with High-Grade Meningioma |
title_sort | role of adjuvant treatment in patients with high-grade meningioma |
topic | Clinical Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594630/ https://www.ncbi.nlm.nih.gov/pubmed/28881115 http://dx.doi.org/10.3340/jkns.2016.1111.009 |
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