Cargando…

SRSF2 directly inhibits intron splicing to suppresses cassette exon inclusion

SRSF2, a Serine-Arginine rich (SR) protein, is a splicing activator that mediates exon inclusion and exclusion events equally well. Here we show SRSF2 directly suppresses intron splicing to suppress cassette exon inclusion in SMN pre-mRNA. Through a serial mutagenesis, we demonstrate that a 10 nt RN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moon, Heegyum, Cho, Sunghee, Loh, Tiing Jen, Jang, Ha Na, Liu, Yongchao, Choi, Namjeong, Oh, Jagyeong, Ha, Jiyeon, Zhou, Jianhua, Cho, Sungchan, Kim, Dong-Eun, Ye, Michael B., Zheng, Xuexiu, Shen, Haihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595172/ https://www.ncbi.nlm.nih.gov/pubmed/28712387 http://dx.doi.org/10.5483/BMBRep.2017.50.8.103

Ejemplares similares

Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping
por: Moon, Heegyum, et al.
Publicado: (2019)

SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon
por: Ha, Jiyeon, et al.
Publicado: (2021)

Opposite Roles of Tra2β and SRSF9 in the v10 Exon Splicing of CD44
por: Oh, Jagyeong, et al.
Publicado: (2020)

Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA
por: Choi, Namjeong, et al.
Publicado: (2021)

RRM but not the Asp/Glu domain of hnRNP C(1)/C(2) is required for splicing regulation of Ron exon 11 pre-mRNA
por: Moon, Heegyum, et al.
Publicado: (2019)

A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene
por: MOON, HEEGYUM, et al.
Publicado: (2014)

hnRNP A1 Regulates Alternative Splicing of Tau Exon 10 by Targeting 3′ Splice Sites
por: Liu, Yongchao, et al.
Publicado: (2020)

SRSF6 Regulates the Alternative Splicing of the Apoptotic Fas Gene by Targeting a Novel RNA Sequence
por: Choi, Namjeong, et al.
Publicado: (2022)

SR proteins regulate V(6) exon splicing of CD44 pre-mRNA
por: Loh, Tiing Jen, et al.
Publicado: (2016)

U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing
por: Choi, Namjeong, et al.
Publicado: (2020)

3′ Splice Site Sequences of Spinal Muscular Atrophy Related SMN2 Pre-mRNA Include Enhancers for Nearby Exons
por: Cho, Sunghee, et al.
Publicado: (2014)

Polypyrimidine tract binding protein inhibits IgM pre-mRNA splicing by diverting U2 snRNA base-pairing away from the branch point
por: Zheng, Xuexiu, et al.
Publicado: (2014)

Identification of Regulatory-RNAs for Alternative Splicing of Ron Proto-Oncogene
por: Moon, Heegyum, et al.
Publicado: (2015)

SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA
por: LOH, TIING JEN, et al.
Publicado: (2014)

Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells
por: Oh, Jagyeong, et al.
Publicado: (2021)

Global Alternative Splicing Defects in Human Breast Cancer Cells
por: Oh, Jagyeong, et al.
Publicado: (2021)

Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia
por: de Oliveira Freitas Machado, Camila, et al.
Publicado: (2023)

SRSF3 Is a Critical Requirement for Inclusion of Exon 3 of BIS Pre-mRNA
por: Baek, Ji-Ye, et al.
Publicado: (2020)

Histone modifications involved in cassette exon inclusions: a quantitative and interpretable analysis
por: Liu, Hui, et al.
Publicado: (2014)

CRISPR as a strong gene editing tool
por: Shen, Shengfu, et al.
Publicado: (2017)

Comparative Analysis and Classification of Cassette Exons and Constitutive Exons
por: Cui, Ying, et al.
Publicado: (2017)

Cooperative Binding of SRSF3 to Structured 3’ss-α Exon RNA during α Exon Inclusion in the ZO-1 mRNA
por: Ruiz-Luis, Tea Anastasia, et al.
Publicado: (2023)

Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma
por: Graham, Garrett T, et al.
Publicado: (2022)

SR protein-mediated inhibition of CFTR exon 9 inclusion: molecular characterization of the intronic splicing silencer
por: Buratti, Emanuele, et al.
Publicado: (2007)

Evolution of Exon-Intron Structure and Alternative Splicing
por: Koralewski, Tomasz E., et al.
Publicado: (2011)

Inhibition of the expression of oncogene SRSF3 by blocking an exonic splicing suppressor with antisense oligonucleotides
por: Guo, Jihua, et al.
Publicado: (2018)

SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA
por: Lei, Sijia, et al.
Publicado: (2021)

The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma
por: Chang, Cunjie, et al.
Publicado: (2022)

A unified mechanism for intron and exon definition and back-splicing
por: Li, Xueni, et al.
Publicado: (2019)

SRSF1 suppresses selection of intron-distal 5′ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein
por: Ahsan, Khalid Bin, et al.
Publicado: (2017)

Splicing Enhancers at Intron–Exon Borders Participate in Acceptor Splice Sites Recognition
por: Kováčová, Tatiana, et al.
Publicado: (2020)

Inclusion of hnRNP L Alternative Exon 7 Is Associated with Good Prognosis and Inhibited by Oncogene SRSF3 in Head and Neck Squamous Cell Carcinoma
por: Xu, Lingfeng, et al.
Publicado: (2019)

Improved identification of conserved cassette exons using Bayesian networks
por: Sinha, Rileen, et al.
Publicado: (2008)

Spatial mapping of splicing factor complexes involved in exon and intron definition
por: Ellis, Jonathan D., et al.
Publicado: (2008)

Acute depletion of METTL3 implicates N(6)-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome
por: Wei, Guifeng, et al.
Publicado: (2021)

SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome
por: Rahman, Mohammad Alinoor, et al.
Publicado: (2015)

Analysis of alternative splicing of cassette exons at single-cell level using two fluorescent proteins
por: Gurskaya, Nadya G., et al.
Publicado: (2012)

Characterizing exons and introns by regularity of nucleotide strings
por: Woods, Tonya, et al.
Publicado: (2016)

Evolution of the Exon-Intron Structure in Ciliate Genomes
por: Bondarenko, Vladyslav S., et al.
Publicado: (2016)

IntEREst: intron-exon retention estimator
por: Oghabian, Ali, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_oth5ccsbdgddbkvmapmf681jqg