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Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration

PURPOSE: There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but no prospective studies have explored the impact of vitamin D. We evaluated the association between vitamin D intake and progression to advanced AMD. METHODS: Among 2146 participants (3965...

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Autores principales: Merle, Bénédicte M. J., Silver, Rachel E., Rosner, Bernard, Seddon, Johanna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595226/
https://www.ncbi.nlm.nih.gov/pubmed/28892825
http://dx.doi.org/10.1167/iovs.17-21673
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author Merle, Bénédicte M. J.
Silver, Rachel E.
Rosner, Bernard
Seddon, Johanna M.
author_facet Merle, Bénédicte M. J.
Silver, Rachel E.
Rosner, Bernard
Seddon, Johanna M.
author_sort Merle, Bénédicte M. J.
collection PubMed
description PURPOSE: There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but no prospective studies have explored the impact of vitamin D. We evaluated the association between vitamin D intake and progression to advanced AMD. METHODS: Among 2146 participants (3965 eyes), 541 (777 eyes) progressed from early or intermediate AMD to advanced disease (mean follow-up: 9.4 years) based on ocular imaging. Nutrients were log transformed and calorie adjusted. Survival analysis was used to assess associations between incident advanced disease and vitamin D intake. Neovascular disease (NV) and geographic atrophy (GA) were evaluated separately. Combined effects of dietary vitamin D and calcium were assessed based on high or low consumption of each nutrient. RESULTS: There was a lower risk of progression to advanced AMD in the highest versus lowest quintile of dietary vitamin D intake after adjustment for demographic, behavioral, ocular, and nutritional factors (hazard ratio [HR]: 0.60; 95% confidence interval [CI]: 0.43–0.83; P trend = 0.0007). Similar results were observed for NV (HR: 0.59; 95% CI: 0.39–0.89; P trend = 0.005) but not GA (HR: 0.83; 95% CI: 0.53–1.30; P trend = 0.35). A protective effect was observed for advanced AMD among participants with high vitamin D and low calcium compared to the group with low levels for each nutrient (HR: 0.67; 95% CI: 0.50–0.88; P = 0.005). When supplement use was considered, the effect was in the protective direction but was not significant. CONCLUSIONS: A diet rich in vitamin D may prevent or delay progression to advanced AMD, especially NV. Additional exploration is needed to elucidate the potential protective role of vitamin D and its contribution to reducing visual loss.
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spelling pubmed-55952262017-09-14 Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration Merle, Bénédicte M. J. Silver, Rachel E. Rosner, Bernard Seddon, Johanna M. Invest Ophthalmol Vis Sci Clinical and Epidemiologic Research PURPOSE: There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but no prospective studies have explored the impact of vitamin D. We evaluated the association between vitamin D intake and progression to advanced AMD. METHODS: Among 2146 participants (3965 eyes), 541 (777 eyes) progressed from early or intermediate AMD to advanced disease (mean follow-up: 9.4 years) based on ocular imaging. Nutrients were log transformed and calorie adjusted. Survival analysis was used to assess associations between incident advanced disease and vitamin D intake. Neovascular disease (NV) and geographic atrophy (GA) were evaluated separately. Combined effects of dietary vitamin D and calcium were assessed based on high or low consumption of each nutrient. RESULTS: There was a lower risk of progression to advanced AMD in the highest versus lowest quintile of dietary vitamin D intake after adjustment for demographic, behavioral, ocular, and nutritional factors (hazard ratio [HR]: 0.60; 95% confidence interval [CI]: 0.43–0.83; P trend = 0.0007). Similar results were observed for NV (HR: 0.59; 95% CI: 0.39–0.89; P trend = 0.005) but not GA (HR: 0.83; 95% CI: 0.53–1.30; P trend = 0.35). A protective effect was observed for advanced AMD among participants with high vitamin D and low calcium compared to the group with low levels for each nutrient (HR: 0.67; 95% CI: 0.50–0.88; P = 0.005). When supplement use was considered, the effect was in the protective direction but was not significant. CONCLUSIONS: A diet rich in vitamin D may prevent or delay progression to advanced AMD, especially NV. Additional exploration is needed to elucidate the potential protective role of vitamin D and its contribution to reducing visual loss. The Association for Research in Vision and Ophthalmology 2017-09 /pmc/articles/PMC5595226/ /pubmed/28892825 http://dx.doi.org/10.1167/iovs.17-21673 Text en Copyright 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Clinical and Epidemiologic Research
Merle, Bénédicte M. J.
Silver, Rachel E.
Rosner, Bernard
Seddon, Johanna M.
Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration
title Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration
title_full Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration
title_fullStr Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration
title_full_unstemmed Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration
title_short Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration
title_sort associations between vitamin d intake and progression to incident advanced age-related macular degeneration
topic Clinical and Epidemiologic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595226/
https://www.ncbi.nlm.nih.gov/pubmed/28892825
http://dx.doi.org/10.1167/iovs.17-21673
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