Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report

Urothelial carcinoma of the bladder (UCB) with glandular differentiation is a histological variant (HV) that is more likely to have positive extravesical tumors or nodes than those in pure UCB. Cisplatin-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) is more effective for pure...

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Autores principales: Fukuhara, Hiroki, Kakizaki, Hiroshi, Kaneko, Hisashi, Yamanobe, Takuya, Ushijima, Masaki, Kuboki, Yuya, Tsuchiya, Norihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595231/
https://www.ncbi.nlm.nih.gov/pubmed/28932689
http://dx.doi.org/10.1016/j.eucr.2017.08.001
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author Fukuhara, Hiroki
Kakizaki, Hiroshi
Kaneko, Hisashi
Yamanobe, Takuya
Ushijima, Masaki
Kuboki, Yuya
Tsuchiya, Norihiko
author_facet Fukuhara, Hiroki
Kakizaki, Hiroshi
Kaneko, Hisashi
Yamanobe, Takuya
Ushijima, Masaki
Kuboki, Yuya
Tsuchiya, Norihiko
author_sort Fukuhara, Hiroki
collection PubMed
description Urothelial carcinoma of the bladder (UCB) with glandular differentiation is a histological variant (HV) that is more likely to have positive extravesical tumors or nodes than those in pure UCB. Cisplatin-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) is more effective for pure UCB; however, few reports are available on second-line chemotherapy for recurrence of UCB with HV. Here we report a 65-year-old Japanese male diagnosed with local recurrence UCB with HV after NAC + RC who safely achieved complete response with paclitaxel, carboplatin, and gemcitabine combination chemotherapy.
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spelling pubmed-55952312017-09-20 Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report Fukuhara, Hiroki Kakizaki, Hiroshi Kaneko, Hisashi Yamanobe, Takuya Ushijima, Masaki Kuboki, Yuya Tsuchiya, Norihiko Urol Case Rep Oncology Urothelial carcinoma of the bladder (UCB) with glandular differentiation is a histological variant (HV) that is more likely to have positive extravesical tumors or nodes than those in pure UCB. Cisplatin-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) is more effective for pure UCB; however, few reports are available on second-line chemotherapy for recurrence of UCB with HV. Here we report a 65-year-old Japanese male diagnosed with local recurrence UCB with HV after NAC + RC who safely achieved complete response with paclitaxel, carboplatin, and gemcitabine combination chemotherapy. Elsevier 2017-09-08 /pmc/articles/PMC5595231/ /pubmed/28932689 http://dx.doi.org/10.1016/j.eucr.2017.08.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Fukuhara, Hiroki
Kakizaki, Hiroshi
Kaneko, Hisashi
Yamanobe, Takuya
Ushijima, Masaki
Kuboki, Yuya
Tsuchiya, Norihiko
Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report
title Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report
title_full Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report
title_fullStr Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report
title_full_unstemmed Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report
title_short Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report
title_sort successful treatment with paclitaxel, carboplatin, and gemcitabine as second-line chemotherapy for recurrent urothelial carcinoma of the bladder with glandular differentiation after radical cystectomy: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595231/
https://www.ncbi.nlm.nih.gov/pubmed/28932689
http://dx.doi.org/10.1016/j.eucr.2017.08.001
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