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Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis
INTRODUCTION: There are controversial results about the role of serum leptin and adiponectin levels as biomarkers of the severity of proteinuria in lupus nephritis. OBJECTIVE: The aim of this study was to evaluate the relationship between serum leptin and adiponectin levels with severity of proteinu...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595281/ https://www.ncbi.nlm.nih.gov/pubmed/28898254 http://dx.doi.org/10.1371/journal.pone.0184056 |
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author | Diaz-Rizo, Valeria Bonilla-Lara, David Gonzalez-Lopez, Laura Sanchez-Mosco, Dalia Fajardo-Robledo, Nicte S. Perez-Guerrero, Edsaul E. Rodriguez-Jimenez, N. Alejandra Saldaña-Cruz, A. Miriam Vazquez-Villegas, M. Luisa Gomez-Bañuelos, Eduardo Vazquez-Del Mercado, Monica Cardona-Muñoz, E. German Cardona-Muller, David Trujillo, Xochitl Huerta, Miguel Salazar-Paramo, Mario Gamez-Nava, Jorge I. |
author_facet | Diaz-Rizo, Valeria Bonilla-Lara, David Gonzalez-Lopez, Laura Sanchez-Mosco, Dalia Fajardo-Robledo, Nicte S. Perez-Guerrero, Edsaul E. Rodriguez-Jimenez, N. Alejandra Saldaña-Cruz, A. Miriam Vazquez-Villegas, M. Luisa Gomez-Bañuelos, Eduardo Vazquez-Del Mercado, Monica Cardona-Muñoz, E. German Cardona-Muller, David Trujillo, Xochitl Huerta, Miguel Salazar-Paramo, Mario Gamez-Nava, Jorge I. |
author_sort | Diaz-Rizo, Valeria |
collection | PubMed |
description | INTRODUCTION: There are controversial results about the role of serum leptin and adiponectin levels as biomarkers of the severity of proteinuria in lupus nephritis. OBJECTIVE: The aim of this study was to evaluate the relationship between serum leptin and adiponectin levels with severity of proteinuria secondary to lupus nephritis (LN). METHODS: In a cross-sectional study, 103 women with systemic lupus erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients with LN, all of them with proteinuria, versus 73 SLE patients without renal involvement (no LN). A comprehensive set of clinical and laboratory variables was assessed, including serum levels of leptin and adiponectin by ELISA. Multivariate analyses were used to adjust for potential confounders associated with proteinuria in LN. RESULTS: We found higher adiponectin levels in the LN group compared with the no LN group (20.4 ± 10.3 vs 15.6 ± 7.8 μg/mL; p = 0.02), whereas no differences were observed in leptin levels (33.3 ± 31.4 vs 22.5 ± 25.5 ng/mL; p = 0.07). Severity of proteinuria correlated with an increase in adiponectin levels (r = 0.31; p = 0.001), but no correlation was observed with leptin. Adiponectin levels were not related to anti-dsDNA or anti-nucleosome antibodies. In the logistic regression, adiponectin levels were associated with a high risk of proteinuria in SLE (OR = 1.06; 95% CI 1.01–1.12; p = 0.02). Instead, leptin was not associated with LN. CONCLUSION: These findings indicate that adiponectin levels are useful markers associated with proteinuria in LN. Further longitudinal studies are required to identify if these levels are predictive of renal relapse. |
format | Online Article Text |
id | pubmed-5595281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55952812017-09-15 Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis Diaz-Rizo, Valeria Bonilla-Lara, David Gonzalez-Lopez, Laura Sanchez-Mosco, Dalia Fajardo-Robledo, Nicte S. Perez-Guerrero, Edsaul E. Rodriguez-Jimenez, N. Alejandra Saldaña-Cruz, A. Miriam Vazquez-Villegas, M. Luisa Gomez-Bañuelos, Eduardo Vazquez-Del Mercado, Monica Cardona-Muñoz, E. German Cardona-Muller, David Trujillo, Xochitl Huerta, Miguel Salazar-Paramo, Mario Gamez-Nava, Jorge I. PLoS One Research Article INTRODUCTION: There are controversial results about the role of serum leptin and adiponectin levels as biomarkers of the severity of proteinuria in lupus nephritis. OBJECTIVE: The aim of this study was to evaluate the relationship between serum leptin and adiponectin levels with severity of proteinuria secondary to lupus nephritis (LN). METHODS: In a cross-sectional study, 103 women with systemic lupus erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients with LN, all of them with proteinuria, versus 73 SLE patients without renal involvement (no LN). A comprehensive set of clinical and laboratory variables was assessed, including serum levels of leptin and adiponectin by ELISA. Multivariate analyses were used to adjust for potential confounders associated with proteinuria in LN. RESULTS: We found higher adiponectin levels in the LN group compared with the no LN group (20.4 ± 10.3 vs 15.6 ± 7.8 μg/mL; p = 0.02), whereas no differences were observed in leptin levels (33.3 ± 31.4 vs 22.5 ± 25.5 ng/mL; p = 0.07). Severity of proteinuria correlated with an increase in adiponectin levels (r = 0.31; p = 0.001), but no correlation was observed with leptin. Adiponectin levels were not related to anti-dsDNA or anti-nucleosome antibodies. In the logistic regression, adiponectin levels were associated with a high risk of proteinuria in SLE (OR = 1.06; 95% CI 1.01–1.12; p = 0.02). Instead, leptin was not associated with LN. CONCLUSION: These findings indicate that adiponectin levels are useful markers associated with proteinuria in LN. Further longitudinal studies are required to identify if these levels are predictive of renal relapse. Public Library of Science 2017-09-12 /pmc/articles/PMC5595281/ /pubmed/28898254 http://dx.doi.org/10.1371/journal.pone.0184056 Text en © 2017 Diaz-Rizo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Diaz-Rizo, Valeria Bonilla-Lara, David Gonzalez-Lopez, Laura Sanchez-Mosco, Dalia Fajardo-Robledo, Nicte S. Perez-Guerrero, Edsaul E. Rodriguez-Jimenez, N. Alejandra Saldaña-Cruz, A. Miriam Vazquez-Villegas, M. Luisa Gomez-Bañuelos, Eduardo Vazquez-Del Mercado, Monica Cardona-Muñoz, E. German Cardona-Muller, David Trujillo, Xochitl Huerta, Miguel Salazar-Paramo, Mario Gamez-Nava, Jorge I. Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis |
title | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis |
title_full | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis |
title_fullStr | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis |
title_full_unstemmed | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis |
title_short | Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis |
title_sort | serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595281/ https://www.ncbi.nlm.nih.gov/pubmed/28898254 http://dx.doi.org/10.1371/journal.pone.0184056 |
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