Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay

Human APOBEC3G (hA3G) is a cytidine deaminase which inhibits HIV-1 replication. The HIV-1 accessory protein viral infectivity factor (Vif) counteracts with hA3G by targeting it for proteasomal degradation. In this work, we constructed and optimized molecular models of the hA3G dimer and the hA3G–Vif...

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Detalles Bibliográficos
Autores principales: Zhai, Congjie, Ma, Ling, Zhang, Zhixin, Ding, Jiwei, Wang, Jing, Zhang, Yongxin, Li, Xiaoyu, Guo, Fei, Yu, Liyan, Zhou, Jinming, Cen, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595295/
https://www.ncbi.nlm.nih.gov/pubmed/28924551
http://dx.doi.org/10.1016/j.apsb.2017.05.002

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