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A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have diametrically opposed fates. Cells must repair DSBs while blocking the action of telomerase on these ends. Short telomeres must avoid recognition by the DNA damage response while promoting telomerase recruitm...

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Detalles Bibliográficos
Autores principales:	Strecker, Jonathan, Stinus, Sonia, Caballero, Mariana Pliego, Szilard, Rachel K, Chang, Michael, Durocher, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Genes and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595431/ https://www.ncbi.nlm.nih.gov/pubmed/28826474 http://dx.doi.org/10.7554/eLife.23783

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