Molecular conservation of marsupial and eutherian placentation and lactation

Eutherians are often mistakenly termed ‘placental mammals’, but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians and marsupials, although marsupials have a far more complex milk repertoire that facilita...

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Autores principales: Guernsey, Michael W, Chuong, Edward B, Cornelis, Guillaume, Renfree, Marilyn B, Baker, Julie C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595433/
https://www.ncbi.nlm.nih.gov/pubmed/28895534
http://dx.doi.org/10.7554/eLife.27450
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author Guernsey, Michael W
Chuong, Edward B
Cornelis, Guillaume
Renfree, Marilyn B
Baker, Julie C
author_facet Guernsey, Michael W
Chuong, Edward B
Cornelis, Guillaume
Renfree, Marilyn B
Baker, Julie C
author_sort Guernsey, Michael W
collection PubMed
description Eutherians are often mistakenly termed ‘placental mammals’, but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians and marsupials, although marsupials have a far more complex milk repertoire that facilitates morphogenesis of developmentally immature young. In this study, we demonstrate that the anatomically simple tammar placenta expresses a dynamic molecular program that is reminiscent of eutherian placentation, including both fetal and maternal signals. Further, we provide evidence that genes facilitating fetal development and nutrient transport display convergent co-option by placental and mammary gland cell types to optimize offspring success. DOI: http://dx.doi.org/10.7554/eLife.27450.001
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spelling pubmed-55954332017-09-18 Molecular conservation of marsupial and eutherian placentation and lactation Guernsey, Michael W Chuong, Edward B Cornelis, Guillaume Renfree, Marilyn B Baker, Julie C eLife Developmental Biology and Stem Cells Eutherians are often mistakenly termed ‘placental mammals’, but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians and marsupials, although marsupials have a far more complex milk repertoire that facilitates morphogenesis of developmentally immature young. In this study, we demonstrate that the anatomically simple tammar placenta expresses a dynamic molecular program that is reminiscent of eutherian placentation, including both fetal and maternal signals. Further, we provide evidence that genes facilitating fetal development and nutrient transport display convergent co-option by placental and mammary gland cell types to optimize offspring success. DOI: http://dx.doi.org/10.7554/eLife.27450.001 eLife Sciences Publications, Ltd 2017-09-12 /pmc/articles/PMC5595433/ /pubmed/28895534 http://dx.doi.org/10.7554/eLife.27450 Text en © 2017, Guernsey et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology and Stem Cells
Guernsey, Michael W
Chuong, Edward B
Cornelis, Guillaume
Renfree, Marilyn B
Baker, Julie C
Molecular conservation of marsupial and eutherian placentation and lactation
title Molecular conservation of marsupial and eutherian placentation and lactation
title_full Molecular conservation of marsupial and eutherian placentation and lactation
title_fullStr Molecular conservation of marsupial and eutherian placentation and lactation
title_full_unstemmed Molecular conservation of marsupial and eutherian placentation and lactation
title_short Molecular conservation of marsupial and eutherian placentation and lactation
title_sort molecular conservation of marsupial and eutherian placentation and lactation
topic Developmental Biology and Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595433/
https://www.ncbi.nlm.nih.gov/pubmed/28895534
http://dx.doi.org/10.7554/eLife.27450
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