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Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma

BACKGROUND AND STUDY AIMS : Endoscopic treatment is indicated for superficial Barrett’s adenocarcinoma (BA) with a negligible risk of lymph node metastasis (LNM). However, risk factors associated with LNM in superficial BA are still not well characterized. The aim of the current study was to clarify...

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Autores principales: Yamada, Masayoshi, Oda, Ichiro, Tanaka, Hirohito, Abe, Seiichiro, Nonaka, Satoru, Suzuki, Haruhisa, Yoshinaga, Shigetaka, Kuchiba, Aya, Koyanagi, Kazuo, Igaki, Hiroyasu, Taniguchi, Hirokazu, Sekine, Shigeki, Saito, Yutaka, Tachimori, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: © Georg Thieme Verlag KG 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595573/
https://www.ncbi.nlm.nih.gov/pubmed/28924592
http://dx.doi.org/10.1055/s-0043-115388
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author Yamada, Masayoshi
Oda, Ichiro
Tanaka, Hirohito
Abe, Seiichiro
Nonaka, Satoru
Suzuki, Haruhisa
Yoshinaga, Shigetaka
Kuchiba, Aya
Koyanagi, Kazuo
Igaki, Hiroyasu
Taniguchi, Hirokazu
Sekine, Shigeki
Saito, Yutaka
Tachimori, Yuji
author_facet Yamada, Masayoshi
Oda, Ichiro
Tanaka, Hirohito
Abe, Seiichiro
Nonaka, Satoru
Suzuki, Haruhisa
Yoshinaga, Shigetaka
Kuchiba, Aya
Koyanagi, Kazuo
Igaki, Hiroyasu
Taniguchi, Hirokazu
Sekine, Shigeki
Saito, Yutaka
Tachimori, Yuji
author_sort Yamada, Masayoshi
collection PubMed
description BACKGROUND AND STUDY AIMS : Endoscopic treatment is indicated for superficial Barrett’s adenocarcinoma (BA) with a negligible risk of lymph node metastasis (LNM). However, risk factors associated with LNM in superficial BA are still not well characterized. The aim of the current study was to clarify risk factors for LNM of superficial BA. PATIENTS AND METHODS : A retrospective study was conducted in 87 consecutive patients with BA that was resected at National Cancer Center Hospital, Tokyo, Japan between 1990 and 2013. We assessed tumor size, macroscopic type, histological type, tumor depth of invasion, lymphovascular invasion and tumor location to analyze factors associated with LNM. Tumor location was classified into following 2 groups according to Siewert classification: 1) BA of the esophagogastric junction (EGJ-BA) as those having their center within 1 cm proximal from the EGJ; and 2) Esophageal-BA as those having their center at 1 cm or more proximal to the EGJ. EGJ was defined as distal end of the palisade vessels. RESULTS:  LNM was detected in 10 (11 %) patients. Univariable analysis revealed that tumor size, tumor depth of invasion, histological type of mixed differentiated and undifferentiated-type adenocarcinoma, lymphovascular invasion and tumor location of esophageal-BA were significantly associated with LNM. Multivariable analysis revealed that tumor location of esophageal-BA [odds ratio 7.8 (95 %CI: 1.3 – 48.1)] was a potential risk factor for LNM. CONCLUSIONS : The current study demonstrated that tumor location is a potential risk factor for LNM in BA. Therefore, indications for endoscopic treatment of esophageal-BA and EGJ-BA could be different.
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spelling pubmed-55955732017-09-18 Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma Yamada, Masayoshi Oda, Ichiro Tanaka, Hirohito Abe, Seiichiro Nonaka, Satoru Suzuki, Haruhisa Yoshinaga, Shigetaka Kuchiba, Aya Koyanagi, Kazuo Igaki, Hiroyasu Taniguchi, Hirokazu Sekine, Shigeki Saito, Yutaka Tachimori, Yuji Endosc Int Open BACKGROUND AND STUDY AIMS : Endoscopic treatment is indicated for superficial Barrett’s adenocarcinoma (BA) with a negligible risk of lymph node metastasis (LNM). However, risk factors associated with LNM in superficial BA are still not well characterized. The aim of the current study was to clarify risk factors for LNM of superficial BA. PATIENTS AND METHODS : A retrospective study was conducted in 87 consecutive patients with BA that was resected at National Cancer Center Hospital, Tokyo, Japan between 1990 and 2013. We assessed tumor size, macroscopic type, histological type, tumor depth of invasion, lymphovascular invasion and tumor location to analyze factors associated with LNM. Tumor location was classified into following 2 groups according to Siewert classification: 1) BA of the esophagogastric junction (EGJ-BA) as those having their center within 1 cm proximal from the EGJ; and 2) Esophageal-BA as those having their center at 1 cm or more proximal to the EGJ. EGJ was defined as distal end of the palisade vessels. RESULTS:  LNM was detected in 10 (11 %) patients. Univariable analysis revealed that tumor size, tumor depth of invasion, histological type of mixed differentiated and undifferentiated-type adenocarcinoma, lymphovascular invasion and tumor location of esophageal-BA were significantly associated with LNM. Multivariable analysis revealed that tumor location of esophageal-BA [odds ratio 7.8 (95 %CI: 1.3 – 48.1)] was a potential risk factor for LNM. CONCLUSIONS : The current study demonstrated that tumor location is a potential risk factor for LNM in BA. Therefore, indications for endoscopic treatment of esophageal-BA and EGJ-BA could be different. © Georg Thieme Verlag KG 2017-09 2017-09-12 /pmc/articles/PMC5595573/ /pubmed/28924592 http://dx.doi.org/10.1055/s-0043-115388 Text en © Thieme Medical Publishers
spellingShingle Yamada, Masayoshi
Oda, Ichiro
Tanaka, Hirohito
Abe, Seiichiro
Nonaka, Satoru
Suzuki, Haruhisa
Yoshinaga, Shigetaka
Kuchiba, Aya
Koyanagi, Kazuo
Igaki, Hiroyasu
Taniguchi, Hirokazu
Sekine, Shigeki
Saito, Yutaka
Tachimori, Yuji
Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma
title Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma
title_full Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma
title_fullStr Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma
title_full_unstemmed Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma
title_short Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma
title_sort tumor location is a risk factor for lymph node metastasis in superficial barrett’s adenocarcinoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595573/
https://www.ncbi.nlm.nih.gov/pubmed/28924592
http://dx.doi.org/10.1055/s-0043-115388
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