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Episodic angioedema associated with eosinophilia
We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595603/ https://www.ncbi.nlm.nih.gov/pubmed/28954105 http://dx.doi.org/10.1590/abd1806-4841.20174351 |
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author | Liu, Fang Hu, Wenxing Liu, Haibo Zhang, Min Sang, Hong |
author_facet | Liu, Fang Hu, Wenxing Liu, Haibo Zhang, Min Sang, Hong |
author_sort | Liu, Fang |
collection | PubMed |
description | We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM, and LDH. Histopathology showed perivascular eosinophilic infiltration and diffuse eosinophilic infiltration throughout the dermis. Possible causes of hypereosinophilia and eosinophilic infiltration of vital organs were ruled out. We also tested the FIP1L1/PDGFRa and ETV6/PDGFRb fusion gene to exclude the possibility of myeloid and lymphatic vessel neoplasms. The patient was treated with methylprednisolone and discharged with an oral prednisolone taper, which resulted in complete remission of the edema and normalization of peripheral blood eosinophil count, serum IL-5 level, IgE, IgM, and LDH. |
format | Online Article Text |
id | pubmed-5595603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-55956032017-09-19 Episodic angioedema associated with eosinophilia Liu, Fang Hu, Wenxing Liu, Haibo Zhang, Min Sang, Hong An Bras Dermatol Case Report We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM, and LDH. Histopathology showed perivascular eosinophilic infiltration and diffuse eosinophilic infiltration throughout the dermis. Possible causes of hypereosinophilia and eosinophilic infiltration of vital organs were ruled out. We also tested the FIP1L1/PDGFRa and ETV6/PDGFRb fusion gene to exclude the possibility of myeloid and lymphatic vessel neoplasms. The patient was treated with methylprednisolone and discharged with an oral prednisolone taper, which resulted in complete remission of the edema and normalization of peripheral blood eosinophil count, serum IL-5 level, IgE, IgM, and LDH. Sociedade Brasileira de Dermatologia 2017 /pmc/articles/PMC5595603/ /pubmed/28954105 http://dx.doi.org/10.1590/abd1806-4841.20174351 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way. |
spellingShingle | Case Report Liu, Fang Hu, Wenxing Liu, Haibo Zhang, Min Sang, Hong Episodic angioedema associated with eosinophilia |
title | Episodic angioedema associated with eosinophilia |
title_full | Episodic angioedema associated with eosinophilia |
title_fullStr | Episodic angioedema associated with eosinophilia |
title_full_unstemmed | Episodic angioedema associated with eosinophilia |
title_short | Episodic angioedema associated with eosinophilia |
title_sort | episodic angioedema associated with eosinophilia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595603/ https://www.ncbi.nlm.nih.gov/pubmed/28954105 http://dx.doi.org/10.1590/abd1806-4841.20174351 |
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