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Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment

γ-Tubulin has a well-established role in nucleating the assembly of microtubules, yet how phosphorylation regulates its activity remains unclear. Here, we use a time-resolved, fitness-based SGA approach to compare two γ-tubulin alleles, and find that the genetic interaction profile of γtub-Y362E is...

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Detalles Bibliográficos
Autores principales:	Shulist, Kristian, Yen, Eric, Kaitna, Susanne, Leary, Allen, Decterov, Alexandra, Gupta, Debarun, Vogel, Jackie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595808/ https://www.ncbi.nlm.nih.gov/pubmed/28900268 http://dx.doi.org/10.1038/s41598-017-11789-7

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