Electrostatics of non-neutral biological microdomains

Voltage and charge distributions in cellular microdomains regulate communications, excitability, and signal transduction. We report here new electrical laws in a biological cell, which follow from a nonlinear electro-diffusion model. These newly discovered laws derive from the geometrical cell-membr...

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Detalles Bibliográficos
Autores principales: Cartailler, J., Schuss, Z., Holcman, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595851/
https://www.ncbi.nlm.nih.gov/pubmed/28900187
http://dx.doi.org/10.1038/s41598-017-11590-6
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author Cartailler, J.
Schuss, Z.
Holcman, D.
author_facet Cartailler, J.
Schuss, Z.
Holcman, D.
author_sort Cartailler, J.
collection PubMed
description Voltage and charge distributions in cellular microdomains regulate communications, excitability, and signal transduction. We report here new electrical laws in a biological cell, which follow from a nonlinear electro-diffusion model. These newly discovered laws derive from the geometrical cell-membrane properties, such as membrane curvature, volume, and surface area. The electro-diffusion laws can now be used to predict and interpret voltage distribution in cellular microdomains such as synapses, dendritic spine, cilia and more.
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spelling pubmed-55958512017-09-14 Electrostatics of non-neutral biological microdomains Cartailler, J. Schuss, Z. Holcman, D. Sci Rep Article Voltage and charge distributions in cellular microdomains regulate communications, excitability, and signal transduction. We report here new electrical laws in a biological cell, which follow from a nonlinear electro-diffusion model. These newly discovered laws derive from the geometrical cell-membrane properties, such as membrane curvature, volume, and surface area. The electro-diffusion laws can now be used to predict and interpret voltage distribution in cellular microdomains such as synapses, dendritic spine, cilia and more. Nature Publishing Group UK 2017-09-12 /pmc/articles/PMC5595851/ /pubmed/28900187 http://dx.doi.org/10.1038/s41598-017-11590-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cartailler, J.
Schuss, Z.
Holcman, D.
Electrostatics of non-neutral biological microdomains
title Electrostatics of non-neutral biological microdomains
title_full Electrostatics of non-neutral biological microdomains
title_fullStr Electrostatics of non-neutral biological microdomains
title_full_unstemmed Electrostatics of non-neutral biological microdomains
title_short Electrostatics of non-neutral biological microdomains
title_sort electrostatics of non-neutral biological microdomains
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595851/
https://www.ncbi.nlm.nih.gov/pubmed/28900187
http://dx.doi.org/10.1038/s41598-017-11590-6
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