ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury

The apolipoprotein E4 (ApoE4) genotype combines with traumatic brain injury (TBI) to increase the risk of developing Alzheimer’s Disease (AD). However, the underlying mechanism(s) is not well-understood. We found that after exposure to repetitive blast-induced TBI, phosphoinositol biphosphate (PIP(2...

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Detalles Bibliográficos
Autores principales: Cao, Jiqing, Gaamouch, Farida El, Meabon, James S., Meeker, Kole D., Zhu, Li, Zhong, Margaret B., Bendik, John, Elder, Gregory, Jing, Ping, Xia, Jiahong, Luo, Wenjie, Cook, David G., Cai, Dongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595858/
https://www.ncbi.nlm.nih.gov/pubmed/28900205
http://dx.doi.org/10.1038/s41598-017-11654-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595858/
https://www.ncbi.nlm.nih.gov/pubmed/28900205
http://dx.doi.org/10.1038/s41598-017-11654-7

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