Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast

Huntington’s disease develops when the polyglutamine (polyQ) repeat in the Huntingtin (Htt) protein is expanded to over 35 glutamines rendering it aggregation-prone. Here, using Htt exon-1 as a polyQ model protein in a genome-wide screen in yeast, we show that the normal and soluble Htt exon-1 is to...

Descripción completa

Detalles Bibliográficos
Autores principales: Berglund, Lisa L., Hao, Xinxin, Liu, Beidong, Grantham, Julie, Nyström, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595923/
https://www.ncbi.nlm.nih.gov/pubmed/28900136
http://dx.doi.org/10.1038/s41598-017-11102-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595923/
https://www.ncbi.nlm.nih.gov/pubmed/28900136
http://dx.doi.org/10.1038/s41598-017-11102-6

Ejemplares similares