Cargando…

The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis

Lipid metabolism is increasingly being appreciated to affect immunoregulation, inflammation and pathology. In this study we found that mice infected with lymphocytic choriomeningitis virus (LCMV) exhibit global perturbations of circulating serum lipids. Mice lacking the lipid-sensing surface recepto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kosack, Lindsay, Gawish, Riem, Lercher, Alexander, Vilagos, Bojan, Hladik, Anastasiya, Lakovits, Karin, Bhattacharya, Anannya, Schliehe, Christopher, Mesteri, Ildiko, Knapp, Sylvia, Bergthaler, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595927/ https://www.ncbi.nlm.nih.gov/pubmed/28900132 http://dx.doi.org/10.1038/s41598-017-10637-y

Ejemplares similares

The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection
por: Schliehe, Christopher, et al.
Publicado: (2014)

Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein
por: Khamina, Kseniya, et al.
Publicado: (2017)

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia
por: Sharif, Omar, et al.
Publicado: (2014)

A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4
por: Gawish, Riem, et al.
Publicado: (2022)

Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages
por: Sharif, Omar, et al.
Publicado: (2021)

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment
por: Saluzzo, Simona, et al.
Publicado: (2017)

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology
por: Gawish, Riem, et al.
Publicado: (2022)

Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
por: Bhattacharya, Anannya, et al.
Publicado: (2015)

T-cell STAT3 is required for the maintenance of humoral immunity to LCMV
por: McIlwain, David R, et al.
Publicado: (2015)

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage
por: Perugorria, Maria J, et al.
Publicado: (2019)

CD8(+) T cells induce cachexia during chronic viral infection
por: Baazim, Hatoon, et al.
Publicado: (2019)

Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge
por: Takayama-Ito, Mutsuyo, et al.
Publicado: (2018)

LCMV Glycosylation Modulates Viral Fitness and Cell Tropism
por: Bonhomme, Cyrille J., et al.
Publicado: (2013)

Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis
por: Lercher, Alexander, et al.
Publicado: (2020)

Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner
por: Watzenboeck, Martin L., et al.
Publicado: (2021)

Identification of a Synthetic Polyhydroxyphenolic Resveratrol Analogue, 3,3′,4,4′,5,5′-Hexahydroxy-trans-Stilbene with Anti-SARS-CoV-2 Activity
por: Jäger, Walter, et al.
Publicado: (2023)

Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models
por: Bocharov, Gennady, et al.
Publicado: (2015)

Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV
por: Hastie, Kathryn M., et al.
Publicado: (2016)

Complexities of Type I Interferon Biology: Lessons from LCMV
por: Suprunenko, Tamara, et al.
Publicado: (2019)

Human cases of lymphocytic choriomeningitis virus (LCMV) infections in Hungary
por: Pankovics, Péter, et al.
Publicado: (2023)

Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus
por: Smyth, Mark, et al.
Publicado: (2021)

TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder
por: You, Yun-Fan, et al.
Publicado: (2023)

Molecular analysis of the interaction of LCMV with its cellular receptor α-dystroglycan
por: Kunz, Stefan, et al.
Publicado: (2001)

The LCMV gp33-specific memory T cell repertoire narrows with age
por: Bunztman, Adam, et al.
Publicado: (2012)

T cells in the brain enhance neonatal mortality during peripheral LCMV infection
por: Kenney, Laurie L., et al.
Publicado: (2021)

Systemic Immunometabolism: Challenges and Opportunities
por: Lercher, Alexander, et al.
Publicado: (2020)

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
por: Kosack, Lindsay, et al.
Publicado: (2019)

Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling
por: Zahalka, Sophie, et al.
Publicado: (2022)

Accelerated and Improved Quantification of Lymphocytic Choriomeningitis Virus (LCMV) Titers by Flow Cytometry
por: Korns Johnson, Darlynn, et al.
Publicado: (2012)

Source Activity Correlation Effects on LCMV Beamformers in a Realistic Measurement Environment
por: Belardinelli, Paolo, et al.
Publicado: (2012)

Difference of two new LCMV strains in lethality and viral genome load in tissues
por: Takagi, Toshikazu, et al.
Publicado: (2017)

Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance
por: Fousteri, Georgia, et al.
Publicado: (2019)

Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants
por: Volland, André, et al.
Publicado: (2021)

B cell–derived IL-27 promotes control of persistent LCMV infection
por: Pratumchai, Isaraphorn, et al.
Publicado: (2022)

LCMV induced downregulation of HVEM on antiviral T cells is critical for an efficient effector response
por: Diethelm, Patrizia, et al.
Publicado: (2022)

IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV
por: Grusdat, M, et al.
Publicado: (2014)

IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection
por: Schmitz, Iwana, et al.
Publicado: (2013)

Role of Lymphocytic Choriomeningitis Virus (LCMV) in Understanding Viral Immunology: Past, Present and Future
por: Zhou, Xin, et al.
Publicado: (2012)

Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries
por: Abdel-Hakeem, Mohamed S.
Publicado: (2019)

Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
por: Perro, Mario, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jvjp33mh8tks79ct19i9jlocnv