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Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study
Although we have found that protease-treated royal jelly (pRJ) benefit for the skeletal muscle mass and strength in the aged animals, the potential beneficial effects have not been evaluated in humans. The aim of this study was to determine whether pRJ intake had beneficial effects on muscle strengt...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595990/ https://www.ncbi.nlm.nih.gov/pubmed/28900247 http://dx.doi.org/10.1038/s41598-017-11415-6 |
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author | Meng, Ge Wang, Honglei Pei, Yinghua Li, Yanmei Wu, Hongmei Song, Yanqi Guo, Qi Guo, Hui Fukushima, Shinobu Tatefuji, Tomoki Wang, Jiazhong Du, Huanmin Su, Qian Zhang, Wen Shen, Suxing Wang, Xiuyang Dong, Renwei Han, Peipei Okazaki, Tatsuma Nagatomi, Ryoichi Wang, Jianhua Huang, Guowei Sun, Zhong Song, Kun Niu, Kaijun |
author_facet | Meng, Ge Wang, Honglei Pei, Yinghua Li, Yanmei Wu, Hongmei Song, Yanqi Guo, Qi Guo, Hui Fukushima, Shinobu Tatefuji, Tomoki Wang, Jiazhong Du, Huanmin Su, Qian Zhang, Wen Shen, Suxing Wang, Xiuyang Dong, Renwei Han, Peipei Okazaki, Tatsuma Nagatomi, Ryoichi Wang, Jianhua Huang, Guowei Sun, Zhong Song, Kun Niu, Kaijun |
author_sort | Meng, Ge |
collection | PubMed |
description | Although we have found that protease-treated royal jelly (pRJ) benefit for the skeletal muscle mass and strength in the aged animals, the potential beneficial effects have not been evaluated in humans. The aim of this study was to determine whether pRJ intake had beneficial effects on muscle strength in elderly nursing home residents. One hundred and ninety-four subjects enrolled into this multicenter, randomized, double-blind, placebo-controlled study. Subjects received either placebo(Group 1), pRJ 1.2 g/d(Group 2), or 4.8 g/d(Group 3). Data through 1 year are reported for 163 subjects. The primary outcome measure is handgrip strength. Secondary outcomes include several physical performance tests (six-minute walk test, timed up and go test, and standing on one leg with eyes closed). The dropout rate was 16.0%. The means (95% confidence interval) of change in handgrip strength for placebo, low-dose, and high-dose groups are −0.98(−2.04,0.08), 0.50(−0.65,1.65) and 1.03(−0.37,2.44) kg (P = 0.06, P for trend = 0.02), respectively. No significant effects of the interventions were observed for physical performances. These findings suggest that pRJ treatment might not improve, but rather attenuate the progression of decrease in muscle strength in elderly people. In addition, we have not found that pRJ intervention can achieve improvement or attenuating the decrease in physical performance. |
format | Online Article Text |
id | pubmed-5595990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55959902017-09-15 Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study Meng, Ge Wang, Honglei Pei, Yinghua Li, Yanmei Wu, Hongmei Song, Yanqi Guo, Qi Guo, Hui Fukushima, Shinobu Tatefuji, Tomoki Wang, Jiazhong Du, Huanmin Su, Qian Zhang, Wen Shen, Suxing Wang, Xiuyang Dong, Renwei Han, Peipei Okazaki, Tatsuma Nagatomi, Ryoichi Wang, Jianhua Huang, Guowei Sun, Zhong Song, Kun Niu, Kaijun Sci Rep Article Although we have found that protease-treated royal jelly (pRJ) benefit for the skeletal muscle mass and strength in the aged animals, the potential beneficial effects have not been evaluated in humans. The aim of this study was to determine whether pRJ intake had beneficial effects on muscle strength in elderly nursing home residents. One hundred and ninety-four subjects enrolled into this multicenter, randomized, double-blind, placebo-controlled study. Subjects received either placebo(Group 1), pRJ 1.2 g/d(Group 2), or 4.8 g/d(Group 3). Data through 1 year are reported for 163 subjects. The primary outcome measure is handgrip strength. Secondary outcomes include several physical performance tests (six-minute walk test, timed up and go test, and standing on one leg with eyes closed). The dropout rate was 16.0%. The means (95% confidence interval) of change in handgrip strength for placebo, low-dose, and high-dose groups are −0.98(−2.04,0.08), 0.50(−0.65,1.65) and 1.03(−0.37,2.44) kg (P = 0.06, P for trend = 0.02), respectively. No significant effects of the interventions were observed for physical performances. These findings suggest that pRJ treatment might not improve, but rather attenuate the progression of decrease in muscle strength in elderly people. In addition, we have not found that pRJ intervention can achieve improvement or attenuating the decrease in physical performance. Nature Publishing Group UK 2017-09-12 /pmc/articles/PMC5595990/ /pubmed/28900247 http://dx.doi.org/10.1038/s41598-017-11415-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Meng, Ge Wang, Honglei Pei, Yinghua Li, Yanmei Wu, Hongmei Song, Yanqi Guo, Qi Guo, Hui Fukushima, Shinobu Tatefuji, Tomoki Wang, Jiazhong Du, Huanmin Su, Qian Zhang, Wen Shen, Suxing Wang, Xiuyang Dong, Renwei Han, Peipei Okazaki, Tatsuma Nagatomi, Ryoichi Wang, Jianhua Huang, Guowei Sun, Zhong Song, Kun Niu, Kaijun Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study |
title | Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study |
title_full | Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study |
title_fullStr | Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study |
title_full_unstemmed | Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study |
title_short | Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study |
title_sort | effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: a randomized, double-blind, placebo-controlled, dose-response study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595990/ https://www.ncbi.nlm.nih.gov/pubmed/28900247 http://dx.doi.org/10.1038/s41598-017-11415-6 |
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