Cargando…

Arginase-II Deficiency Extends Lifespan in Mice

The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66(Shc) and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-II on organismal lifespan is not known. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiong, Yuyan, Yepuri, Gautham, Montani, Jean-Pierre, Ming, Xiu-Fen, Yang, Zhihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596098/ https://www.ncbi.nlm.nih.gov/pubmed/28943853 http://dx.doi.org/10.3389/fphys.2017.00682

Ejemplares similares

Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity
por: Huang, Ji, et al.
Publicado: (2016)

Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis
por: Carvas, João M., et al.
Publicado: (2012)

Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis
por: Yu, Yi, et al.
Publicado: (2018)

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis
por: Ming, Xiu‐Fen, et al.
Publicado: (2012)

ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
por: Xiong, Yuyan, et al.
Publicado: (2015)

Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability
por: Xiong, Yuyan, et al.
Publicado: (2013)

Role of p38 mitogen-activated protein kinase in vascular endothelial aging: Interaction with Arginase-II and S6K1 signaling pathway
por: Wu, Zongsong, et al.
Publicado: (2015)

Arginase-II negatively regulates renal aquaporin-2 and water reabsorption
por: Huang, Ji, et al.
Publicado: (2018)

Hypoxia Enhances Endothelial Intercellular Adhesion Molecule 1 Protein Level Through Upregulation of Arginase Type II and Mitochondrial Oxidative Stress
por: Liang, Xiujie, et al.
Publicado: (2019)

Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling
por: Xiong, Yuyani, et al.
Publicado: (2014)

p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity
por: Yu, Yi, et al.
Publicado: (2014)

Hypoxia Induces Renal Epithelial Injury and Activates Fibrotic Signaling Through Up-Regulation of Arginase-II
por: Liang, Xiujie, et al.
Publicado: (2021)

Perspectives of Targeting mTORC1–S6K1 in Cardiovascular Aging
por: Ming, Xiu-Fen, et al.
Publicado: (2012)

Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation
por: Liu, Chang, et al.
Publicado: (2016)

Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling
por: Zhu, Cuicui, et al.
Publicado: (2017)

Elevation of Arginase-II in Podocytes Contributes to Age-Associated Albuminuria in Male Mice
por: Ajalbert, Guillaume, et al.
Publicado: (2023)

Role of tubular epithelial arginase-II in renal inflammaging
por: Huang, Ji, et al.
Publicado: (2021)

Role of Arginase-II in Podocyte Injury under Hypoxic Conditions
por: Ren, Zhilong, et al.
Publicado: (2022)

Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation
por: Yang, Zhihong, et al.
Publicado: (2013)

Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol
por: Rajapakse, Angana G., et al.
Publicado: (2011)

Role of pulmonary epithelial arginase‐II in activation of fibroblasts and lung inflammaging
por: Zhu, Cui, et al.
Publicado: (2023)

A standardized approach to study human variability in isometric thermogenesis during low-intensity physical activity
por: Sarafian, Delphine, et al.
Publicado: (2013)

Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders
por: Yang, Zhihong, et al.
Publicado: (2014)

C22 disrupts embryogenesis and extends C. elegans lifespan
por: Beydoun, Safa, et al.
Publicado: (2023)

Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline
por: Ming, Xiu-Fen, et al.
Publicado: (2009)

Deuterated Polyunsaturated Fatty Acids Reduce Oxidative Stress and Extend the Lifespan of C. elegans
por: Beaudoin-Chabot, Caroline, et al.
Publicado: (2019)

Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster
por: Begum, Rana, et al.
Publicado: (2015)

Paracrine Effects of Renal Proximal Tubular Epithelial Cells on Podocyte Injury under Hypoxic Conditions Are Mediated by Arginase-II and TGF-β1
por: Ma, Yiqiong, et al.
Publicado: (2023)

Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart
por: Schlüter, Klaus-Dieter, et al.
Publicado: (2015)

Caloric Restriction Extends Yeast Chronological Lifespan by Altering a Pattern of Age-Related Changes in Trehalose Concentration
por: Kyryakov, Pavlo, et al.
Publicado: (2012)

Plasmatic Concentrations of ADMA and Homocystein in Llama (Lama glama) and Regulation of Arginase Type II: An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia
por: López, Vasthi, et al.
Publicado: (2018)

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
por: Ghosh, Shrestha, et al.
Publicado: (2018)

Strategies to Rescue the Consequences of Inducible Arginase-1 Deficiency in Mice
por: Ballantyne, Laurel L., et al.
Publicado: (2015)

S100A9 extends lifespan in insulin deficiency
por: Ramadori, Giorgio, et al.
Publicado: (2019)

Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition
por: Krause, Bernardo J., et al.
Publicado: (2018)

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1
por: Cheng, Hong, et al.
Publicado: (2020)

Endothelial arginase II and atherosclerosis
por: Ryoo, Sungwoo, et al.
Publicado: (2011)

Cardiovascular and Cutaneous Responses to the Combination of Alcohol and Soft Drinks: The Way to Orthostatic Intolerance?
por: Maufrais, Claire, et al.
Publicado: (2017)

Early and Late Cardiovascular and Metabolic Responses to Mixed Wine: Effect of Drink Temperature
por: Sarafian, Delphine, et al.
Publicado: (2018)

Arginase Deficiency Presenting as Acute Encephalopathy
por: Cornelius, Leema Pauline, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5fdmsdq9i6ue7qj51j1sl7i47g