VEGFA links self-renewal and metastasis by inducing Sox2 to repress miR-452, driving Slug

Cancer stem cells (CSC) appear to have increased metastatic potential, but mechanisms underlying this are poorly defined. Here we show that VEGFA induction of Sox2 promotes EMT and tumor metastasis. In breast lines and primary cancer culture, VEGFA rapidly upregulates SOX2 expression, leading to SNA...

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Detalles Bibliográficos
Autores principales: Kim, M, Jang, K, Miller, P, Picon-Ruiz, M, Yeasky, T M, El-Ashry, D, Slingerland, J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596211/
https://www.ncbi.nlm.nih.gov/pubmed/28504716
http://dx.doi.org/10.1038/onc.2017.4

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